Immunoregulation of NKT Cells in Systemic Lupus Erythematosus

Journal of Immunology Research
Junwei ChenXiaofeng Li

Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with different variety of clinical manifestations. Natural killer T (NKT) cells are innate lymphocytes that play a regulatory role during broad range of immune responses. A number of studies demonstrated that the quantity and quality of invariant NKT (iNKT) cells showed marked defects in SLE patients in comparison to healthy controls. This finding suggests that iNKT cells may play a regulatory role in the occurrence and development of this disease. In this review, we mainly summarized the most recent findings about the behavior of NKT cells in SLE patients and mouse models, as well as how NKT cells affect the proportion of T helper cells and the production of autoreactive antibodies in the progress of SLE. This will help people better understand the role of NKT cells in the development of SLE and improve the therapy strategy.

References

May 3, 1996·Cell·B L Kotzin
Mar 14, 2000·Immunity·J E GumperzS M Behar
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·K TakedaK Okumura
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D ZengS Strober
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Sep 7, 2000·The Journal of Experimental Medicine·J L MatsudaM Kronenberg
Apr 21, 2001·Cellular and Molecular Life Sciences : CMLS·S Joyce
Jul 24, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·H J van der VlietH M Pinedo
Aug 3, 2002·Nature Reviews. Immunology·Mitchell Kronenberg, Laurent Gapin
Sep 11, 2002·European Journal of Immunology·Sufi Reza M MorshedToru Abo
Sep 6, 2002·Journal of Immunological Methods·Stéphane Sidobre, Mitchell Kronenberg
Jan 25, 2003·Annual Review of Immunology·Masaru TaniguchiHiroshi Wakao
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariette LisbonneMaria C Leite-de-Moraes
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun-Qi YangRam Raj Singh
Jan 28, 2004·The Journal of Experimental Medicine·Emmanuel TupinGabrielle Paulsson Berne
Feb 26, 2004·Journal of Immunological Methods·Paul R RogersShinichiro Kato
Mar 23, 2004·Annual Review of Immunology·Manfred Brigl, Michael B Brenner
Mar 25, 2004·Nature Reviews. Immunology·Dale I GodfreyLuc Van Kaer
Oct 13, 2004·Immunologic Research·Luc Van Kaer
Sep 13, 2005·Trends in Immunology·Ram Raj Singh
Oct 11, 2005·Autoimmunity Reviews·Antonio La CavaBevra H Hahn
Mar 17, 2006·The New England Journal of Medicine·Hong Jiang, Leonard Chess
Dec 8, 2006·Annual Review of Immunology·Albert BendelacLuc Teyton
Feb 3, 2007·European Journal of Immunology·Guido SireciAlfredo Salerno
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ian F HermansVincenzo Cerundolo
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan M CoquetDale I Godfrey
May 2, 2007·The Journal of Experimental Medicine·Marie-Laure MichelMaria C Leite-de-Moraes
Sep 26, 2007·Annals of the New York Academy of Sciences·Véronique PariettiFanny Monneaux
Apr 1, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Chun Kwok WongChristopher Wai Kei Lam
May 27, 2008·Current Opinion in Immunology·Jennifer L MatsudaLaurent Gapin
Dec 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marie-Laure MichelMaria C Leite-de-Moraes
Feb 10, 2009·Current Molecular Medicine·Lan Wu, Luc Van Kaer
May 1, 2009·Arthritis and Rheumatism·Ji YangMing Li
Jul 25, 2009·Expert Review of Vaccines·Mark L Lang
Feb 9, 2010·Nature Immunology·Dale I GodfreyAlan G Baxter
May 5, 2010·The Journal of Experimental Medicine·Fredrik WermelingMikael C I Karlsson

❮ Previous
Next ❯

Citations

Apr 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zeynab Aliyari SerejHojjatollah Nozad Charoudeh
May 24, 2017·Lupus·M R Salaman, D A Isenberg
Sep 4, 2018·Expert Review of Clinical Immunology·Iris L A Bodewes, Marjan A Versnel
Mar 14, 2019·Journal of Cellular Physiology·Saeid ShahrabiElham Rajaei
Dec 15, 2016·Frontiers in Immunology·Sara De BiasiAndrea Cossarizza
Mar 28, 2017·The Journal of International Medical Research·A Di Stadio, Massimo Ralli
Jun 20, 2017·Frontiers in Endocrinology·Domenico SantoroSalvatore Benvenga
May 6, 2017·Clinical Reviews in Allergy & Immunology·Guillermo Carvajal AlegriaDivi Y K Cornec
Jun 18, 2019·Expert Opinion on Investigational Drugs·Sarah PringleFrans G M Kroese
May 30, 2019·International Journal of Molecular Sciences·Takahiro UchidaShuhji Seki
Apr 11, 2017·Current Opinion in Rheumatology·Yahel SegalYehuda Shoenfeld
Dec 5, 2020·ImmunoTargets and Therapy·André Jefremow, Markus F Neurath
Feb 13, 2021·Scandinavian Journal of Immunology·Nikoo Hossein-KhannazerGholamreza Azizi
Mar 16, 2021·American Journal of Physiology. Renal Physiology·Jung Nam AnSeung Hee Yang
May 29, 2021·Future Science OA·Yanni JiangXianming Mo
Nov 16, 2021·Frontiers in Immunology·Dorien FeyaertsRenate G van der Molen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.