PMID: 6165262Jan 1, 1980Paper

Immunoregulatory action of type I interferon in the mouse

Annals of the New York Academy of Sciences
E De Maeyer, J De Maeyer-Guignard

Abstract

The effect of type I interferon production on immunity to the interferon-inducing virus was examined using the Newcastle disease virus [NDV]-mouse model and comparing If-1h and If-1l animals. The degree of cell-mediated immunity, as measured by delayed hypersensitivity [DH] to NDV, was influenced by the levels of interferon produced. Anti-interferon globulin given immediately after immunization decreased sensitization to NDV, whereas additional, exogenous, interferon, given to low interferon producers, stimulated sensitization to NDV. The alleles at the If-1 locus influenced the extent of DH to NDV, in that If-1h mice developed much stronger DH than did If-1l mice. However, results from recombinant inbred strains, F2 and backcross generations showed that for interferon production to stimulate DH to NDV, other genes, present in the C57BL/6 background but as yet not characterized, are required. Thus DH to NDV is determined on the one hand by the alleles at If-1, influencing interferon production, and on the other hand by a combination of several genes affecting the interaction of interferon with cells of the immune system.

References

Jan 1, 1975·Advances in Immunology·A J Crowle
Jan 1, 1977·Contemporary Topics in Immunobiology·H Cantor, E Boyse
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E De MaeyerM Vandeputte
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J De Maeyer-GuignardE De Maeyer
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I GresserE De Maeyer
Mar 1, 1977·Cellular Immunology·M RabinovitchE E Abbey
Jun 1, 1976·The Journal of Infectious Diseases·E De Maeyer
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P LindahlI Gresser
Mar 1, 1974·The Journal of Experimental Medicine·P H LagrangeT E Miller
Jul 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·J de Maeyer-GuignardP Jullien
May 1, 1969·Journal of Virology·E de Maeyer, J de Maeyer-Guignard
Sep 1, 1977·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·T E Ferrari, D H Wallace

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Citations

Apr 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·A M SorokinG V Shchurina
Jan 1, 1983·Journal of Interferon Research·E De Maeyer
Jan 1, 1983·Journal of Interferon Research·I HeronK Berg
Oct 1, 1987·Journal of Interferon Research·A Billiau
Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·D M MuraskoR Mark
Jan 1, 1984·The Prostate·J S Horoszewicz
Aug 1, 1986·Cellular Immunology·B M FreedN Lempert
Oct 2, 1981·Science·R B Herberman, J R Ortaldo

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