Immunoregulatory activities of polysaccharides from mung bean

Carbohydrate Polymers
Yang YaoGuixing Ren

Abstract

Ultrasonic treatment was performed on water-extractable polysaccharides from the seed of mung beans. Purified by anion-exchange and gel filtration chromatography, MWP-1' and MWP-2' were obtained. Average molecular weights (Mws) of MWP-1' and MWP-2' were 68.4 kDa, and 52.4 kDa, respectively. Monosaccharides components analysis indicated that MWP-1' was composed of Rha, Ara, Man and Gal in a molar percent of 0.4:2.6:5.3:0.7. MWP-2' was composed of Ara, Man, Gal and Glc in a molar percent of 0.5:1.4:2.1:0.4. In vitro study showed that both polysaccharides samples were able to stimulate the production of secretory molecules (NO, TNF-α and IL-6) of RAW264.7 murine macrophages in a dosage dependent manner. MWP-2' seemed to be the most potent and induced significantly higher the NO production. These findings suggest that the ultrasonic treatment polysaccharides isolated in our study have immune potentiation effects on macrophages.

References

Apr 5, 2001·Trends in Plant Science·D WendehenneJ Durner
Mar 22, 2005·International Immunopharmacology·Ruan ZhengWu Moucheng
Jun 7, 2005·Ultrasonics Sonochemistry·M VodenicarováA Ebringerová
Jan 24, 2006·International Immunopharmacology·Igor A Schepetkin, Mark T Quinn
Nov 11, 2011·International Journal of Molecular Sciences·Yang YaoGuixing Ren
Jan 5, 2012·International Journal of Biological Macromolecules·Rufeng WangFang Ma
Jan 30, 2014·International Journal of Biological Macromolecules·Xiaona YuGuixing Ren
Jul 1, 2015·International Journal of Biological Macromolecules·Yang YaoGuixing Ren

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Citations

Nov 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Heng LiXiangyang Lu
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kaimin LuJinku Bao
Jul 15, 2021·Critical Reviews in Food Science and Nutrition·He LiuDanshi Zhu

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