Immunoregulatory activity in adult rat testicular interstitial fluid: roles of interleukin-1 and transforming growth factor beta

Biology of Reproduction
M P HedgerD M de Kretser

Abstract

Studies on the effect of rat testicular interstitial fluid (IF) on T-cell function have reported both stimulatory and inhibitory actions. Specific cytokines produced within the testis, particularly interleukin-1 (IL-1) and transforming growth factor beta (TGFbeta), may contribute to these apparently conflicting observations. In proliferation assays employing lectin- or antibody-activated thymocytes or mature T cells in vitro, adult rat testicular IF stimulated T-cell activation and/or proliferation at low assay doses and was inhibitory at higher doses. The stimulatory activity was blocked by recombinant IL-1 receptor antagonist. The inhibitory activity was not affected by a polyspecific TGFbeta antiserum. The biological characteristics of the inhibitor were distinct from those of a similar, but considerably less potent, activity in platelet-depleted serum. These data demonstrate that rat testicular IF contains biologically significant concentrations of IL-1 but has a predominantly inhibitory action on T-cell responses. The factor predominantly responsible for this inhibitory activity displays a relatively large apparent molecular weight, is protease sensitive and partially heat labile, but does not appear to be one of the known...Continue Reading

Citations

Sep 14, 1999·Endocrine·D B HalesK H Hales
Oct 19, 2002·Journal of Reproductive Immunology·Mark P Hedger
Jul 27, 2007·International Journal of Andrology·E M GarcíaH Rodríguez-Martínez
May 4, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming WangSudhanshu Bhushan
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Moira K O'BryanMark P Hedger
Jul 17, 2004·Endocrinology·Moira K O'BryanMark P Hedger

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