PMID: 376724May 1, 1979Paper

Immunoregulatory circuits among T cell sets: effect of mode of immunization on determining which Lyl T cell sets will be activated

The Journal of Immunology : Official Journal of the American Association of Immunologists
D D EardleyR K Gershon

Abstract

Lyl T cells are able to induce B cells to make antibody and also to induce a resting Lyl23 T cell set to exert potent feedback suppression. Which of these two pathways Lyl T cells take can be influenced by the mode of immunization. In particular, in vitro immunized Lyl T cells are more likely to induce suppression than are Lyl T cells immunized in vivo even when both populations deliver the same amount of help to purified B cells. The feedback suppression induced by the Lyl T cells immunized in vitro can be distinguished from suppression mediated by Ly2+ T cells; in the former case suppression is preceded by a precocious antibody response, whereas suppression mediated by Ly2+ T cells is apparent throughout the entire period of observation.

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