Immunoregulatory confluence: T cells, Fc receptors and cytokines for IgA immune responses

International Reviews of Immunology
H KiyonoJ R McGhee

Abstract

IgA isotype responses are regulated by at least two compartments including those of CD4+ Th2 type cells and cytokines produced by these cells. Interaction of CD4+ Th cells and APC via TCR and Ag-MHC II leads to activation of Th2 type cells. This would allow for secretion of cytokines, especially IL-5 and IL-6 which are key cytokines for the terminal differentiation of B cells into Ig secreting cells. Further, expression of Fc alpha RII on CD4+ Th2 cells could be important for the recruitment of sIgA+ B cells which would allow selective interactions of Th2 cells and sIgA + B cells via Fc alpha RII. This could lead to selectively transfer of IL-5 and IL-6 to sIgA + B cells from CD4+ Th2 cells.

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Citations

Mar 2, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·James J Pestka
Nov 19, 2010·PLoS Pathogens·Ali AziziJiri Mestecky
Nov 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M E RossiA Vierucci
Nov 28, 2002·Journal of Cutaneous Pathology·A Neil CrowsonN Scott McNutt

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