PMID: 6969795Jan 1, 1981Paper

Immunoregulatory defects in a family with selective IgA deficiency

The Journal of Pediatrics
D Levitt, M D Cooper

Abstract

Defects in regulation of the humoral immune system were examined in a family with selective IgA deficiency. Two patients (mother and son) were clinically well and had selective abnormalities of B lymphocytes that can differentiate into IgA plasma cells plus specific T cell suppression of IgA production. One patient (daughter) had several clinical problems and received nine monthly transfusions of normal plasma. Prior to therapy, this patient had abnormal immunoregulation of both B and T lymphocyte population that cooperated in the formation of all cases of immunoglobulin-producing cells. After treatment, her clinical problems were resolved and her cellular abnormalities appeared identical in those in her mother and brother.

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Citations

May 1, 1984·Journal of Clinical Immunology·T InoueT Yanase
May 1, 1989·Journal of Clinical Immunology·J R McGheeH Kiyono
Sep 1, 1983·Molecular Immunology·M E ConleyS D Douglas
Jul 1, 1982·Cancer Genetics and Cytogenetics·G S SchuelkeE A Chaperon
Aug 27, 1981·The New England Journal of Medicine·M E Conley, M D Cooper
Nov 1, 1983·The Journal of Clinical Investigation·D LevittM D Cooper
Jan 1, 1983·Scandinavian Journal of Rheumatology·P PelkonenA L Mäkelä
Oct 26, 2013·Autoimmunity Reviews·Karmtej SinghM Eric Gershwin
Mar 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S R Porter, C Scully
Sep 1, 1985·Clinical Immunology and Immunopathology·P J FelsburgP F Jezyk
Jun 30, 1983·Annals of the New York Academy of Sciences·M D CooperD E Briles
Mar 1, 1982·Tissue Antigens·K OenM L Schroeder
Jan 1, 1981·Immunological Reviews·W E GathingsM D Cooper
Dec 1, 1983·Scandinavian Journal of Immunology·L HammarströmC I Smith
Feb 1, 1986·Clinical Immunology and Immunopathology·C Cunningham-RundlesL A Hanson

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