Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats

Immunology and Cell Biology
Wei-Min LiBao-Guo Zhou

Abstract

Experimental autoimmune myocarditis (EAM) in rats is a T-cell-mediated disorder and has been shown to involve immune imbalance. The aim of this study was to examine the immunomodulatory effects of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor, atorvastatin, on the expression of MHC class II molecules in the myocardium of rats with EAM, and to examine its therapeutic potential for EAM. EAM was induced in Lewis rats by injection of porcine cardiac myosin. High-dosage (10 mg/kg per day) or low-dosage (1 mg/kg per day) atorvastatin or vehicle was given orally for 3 weeks. On day 21 after immunization, echocardiography was carried out and the severity of myocarditis was evaluated by histopathological investigations. Immunohistochemistry techniques were used to examine the expression of MHC class II molecules in the myocardium. Type I, III and IV class II transactivator (CIITA) promoter transcription was evaluated by reverse transcription-PCR. Cardiomyocytes were isolated and the expression of MHC class II molecules by them was detected using cytometry. Serum Th1/Th2 cytokines were examined on day 21 by ELISA. Cardiac function was improved in the two atorvastatin-treated groups compared with the untreated one. In atorvas...Continue Reading

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Citations

Sep 24, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Alian ZhangShiyao Wu
Mar 3, 2012·Cardiovascular Drugs and Therapy·Xiaoman LiuFengshuang An
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Feb 24, 2021·Progress in Cardiovascular Diseases·Negin ParsamaneshAmirhossein Sahebkar

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