Immunoregulatory Effects of Neuropeptides on Endothelial Cells: Relevance to Dermatological Disorders

Dermatology : International Journal for Clinical and Investigative Dermatology
Devina Mehta, Richard D Granstein

Abstract

Many skin diseases, including psoriasis and atopic dermatitis, have a neurogenic component. In this regard, bidirectional interactions between components of the nervous system and multiple target cells in the skin and elsewhere have been receiving increasing attention. Neuropeptides released by sensory nerves that innervate the skin can directly modulate functions of keratinocytes, Langerhans cells, dermal dendritic cells, mast cells, dermal microvascular endothelial cells and infiltrating immune cells. As a result, neuropeptides and neuropeptide receptors participate in a complex, interdependent network of mediators that modulate the skin immune system, skin inflammation, and wound healing. In this review, we will focus on recent studies demonstrating the roles of α-melanocyte-stimulating hormone, calcitonin gene-related peptide, substance P, somatostatin, vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and nerve growth factor in modulating inflammation and immunity in the skin through their effects on dermal microvascular endothelial cells.

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Citations

Mar 13, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lingjia LiuJia Yin
Aug 9, 2020·Frontiers in Endocrinology·Denes TothDora Reglodi
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May 9, 2021·Experimental Dermatology·Yue ZhangJianyun Lu
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May 21, 2021·Frontiers in Immunology·Luisa F DuartePablo A González
Jun 4, 2021·Clinical, Cosmetic and Investigational Dermatology·Deryne Anggia ParamitaNova Zairina Lubis
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Dec 11, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Matthew MaloneLawrence A Lavery

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