Immunoregulatory effects of the flavonol quercetin in vitro and in vivo.

European Journal of Nutrition
Thomas NickelMichael Weis

Abstract

Atherosclerosis is known to be an inflammatory disease. Dendritic cells (DCs) are essential for the regulation of the immune system. Up to 10% of the cells in atherosclerotic plaques are DCs. The cardiovascular protective effects of flavonoids (tea, wine) may be mediated by anti-inflammatory mechanisms that affect DC regulation. We aimed to characterize the impact of the flavonol quercetin on DC activity and differentiation in vitro and in vivo. For the in vitro experiments, we used murine DCs and endothelial cells to study adhesion properties. For all other experiments (DC phagocytosis capacity, DC maturation, DC differentiation (BDCA-1/-2) and NF-kB-activation), human monocyte-derived DCs were used. The cells were incubated with quercetin (10 μmol/L) ± oxLDL (10 μg/mL) between 24 and 48 h. For in vivo experiments, eight healthy male volunteers took 500 mg of quercetin twice daily over 4 weeks, five healthy male volunteers served as control. Before and after intake, blood samples were collected. Peripheral blood leukocytes were isolated (analyses of DC differentiation), and plasma was immediately frozen. Quercetin reduced DC adhesion (-42%; p < 0.05) and expression of CD11a (-21%; p < 0.05). OxLDL-induced DC differentiation wa...Continue Reading

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Citations

Sep 2, 2011·European Journal of Applied Physiology·Thomas NickelH Hanssen
Nov 2, 2011·Cell Stress & Chaperones·Tongyu Cao WikramanayakeJoaquin J Jimenez
Apr 5, 2011·Mediators of Inflammation·Thomas NickelMichael Weis
May 24, 2012·Mediators of Inflammation·Thomas NickelMichael Weis
Sep 20, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Anna Del PreteCarmelina Loguercio
Mar 5, 2011·European Journal of Pharmacology·Vladimir A KostyukLiudmila G Korkina
Mar 6, 2012·Phytotherapy Research : PTR·Jiyoung MoonMin-Jeong Shin
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Jul 1, 2016·Acta Veterinaria Scandinavica·Ramona BabosovaMonika Martiniakova
Jan 7, 2017·Experimental Biology and Medicine·Tina B McKay, Dimitrios Karamichos
Mar 22, 2019·Journal of Cellular Physiology·Enhui YaoXin Jin
Jul 28, 2019·Current Atherosclerosis Reports·Sanjiv Singh, Avtar Singh Gautam
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Jan 13, 2016·World Journal of Gastroenterology : WJG·Moon-Sun KimXianqin Qu
Jun 8, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Korbinian LackermairThomas Nickel
Dec 21, 2018·Current Medicinal Chemistry·Manuel SánchezJuan Duarte
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Dec 26, 2018·Journal of Cellular Physiology·Yumin ZhaoShigui Chong
Mar 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Maryam Bahram-Parvar, Loong-Tak Lim
May 24, 2019·Journal of Agricultural and Food Chemistry·Michael KaiserAndreas Schieber

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