PMID: 8955488Dec 1, 1996Paper

Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity

American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society
S Grabbe, T Schwarz

Abstract

At first sight, the pathophysiology of contact hypersensitivity (CHS) seems to be well understood. Whereas this may apply to some extent to the sensitization phase of CHS, very little is actually known about the elicitation phase of this response. Although the mechanisms of T-cell priming (sensitization) may be more interesting for immunologists, those involved in the elicitation of T cell-mediated secondary responses are more relevant for clinical management because clinically manifest allergic contact dermatitis always reflects the effector phase of CHS. This review summarizes the role of different cellular components and soluble mediators on the elicitation of CHS. In addition, recent studies revealed that, besides selective activation of antigen-specific T cells, epicutaneous application of haptens has a number of direct effects on the cutaneous immune system. The most relevant of these are induction of cytokine and chemokine secretion and endothelial activation. In an attempt to integrate data on this issue, it is proposed that the capacity of contact allergens to directly induce proinflammatory signals in the skin is of relevance and perhaps essential for elicitation of clinically manifest CHS responses. Moreover, the pro...Continue Reading

References

Jan 1, 1992·Springer Seminars in Immunopathology·N Romani, G Schuler
Jan 26, 1991·Lancet·J N BarkerB J Nickoloff
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A H Enk, S I Katz
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T A FergusonT S Kupper
Jan 1, 1990·International Archives of Allergy and Applied Immunology·M GoebelerC Sorg
May 1, 1990·The British Journal of Dermatology·J McLelland, S Shuster
Sep 1, 1986·The British Journal of Dermatology·C M WillisJ D Wilkinson
Jan 1, 1982·The Journal of Experimental Medicine·D V BelsitoI Gigli
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·I R Williams, T S Kupper
May 1, 1994·International Archives of Allergy and Immunology·S Martin, H U Weltzien
Nov 27, 1994·Transplantation·P BaligaJ S Bromberg
Jun 1, 1995·The Journal of Experimental Medicine·M SubramaniamD D Wagner
Jul 1, 1995·The Journal of Experimental Medicine·D J BergD Rennick
Nov 1, 1994·Contact Dermatitis·R VirabenJ Bazex
Mar 1, 1995·Journal of the American Academy of Dermatology·T H FinesmithR Rietschel
May 1, 1994·The Journal of Experimental Medicine·T A FergusonT S Griffith
Feb 1, 1993·Immunology Today·J D Bos, M L Kapsenberg
Jan 1, 1993·Research in Immunology·M F CesbronA Sher
Apr 1, 1996·European Journal of Immunology·H Reiser, E E Schneeberger
Feb 19, 2013·International Journal of Systematic and Evolutionary Microbiology·Guanghua WangXiang Li

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Citations

Apr 11, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W SteilingC Wiemann
Jul 14, 1999·Toxicology Letters·I KimberR J Dearman
Mar 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C A RyanG F Gerberick
Apr 9, 2002·Australian Family Physician·Mary Christoforou
Aug 26, 2010·Journal of Immunotoxicology·Valentina GalbiatiEmanuela Corsini
Jul 20, 2002·Experimental and Molecular Pathology·Pamela B AsaRobert F Garry
May 8, 2007·Emergency Medicine Clinics of North America·Blake FrobergR Brent Furbee
Mar 25, 2004·Nature Reviews. Immunology·Thomas S Kupper, Robert C Fuhlbrigge
Nov 8, 2003·The Journal of Pharmacy and Pharmacology·E J De LeónM C Terencio
Jul 8, 2005·International Immunology·Kavitha ViswanathanFirdaus S Dhabhar

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