PMID: 15240727Jul 9, 2004Paper

Immunoregulatory role of nitric oxide in Kilham rat virus-induced autoimmune diabetes in DR-BB rats

The Journal of Immunology : Official Journal of the American Association of Immunologists
Israel I MendezJi-Won Yoon

Abstract

Macrophages play a critical role in the pathogenesis of Kilham rat virus (KRV)-induced autoimmune diabetes in diabetes-resistant BioBreeding (DR-BB) rats. This investigation was initiated to determine the role of macrophage-derived soluble mediators, particularly NO, in the pathogenesis of KRV-induced diabetes in DR-BB rats. We found that the expression of inducible NO synthase (iNOS), an enzyme responsible for NO production, was significantly increased during the early phase of KRV infection. Inhibition of iNOS by aminoguanidine (AG) treatment resulted in the prevention of diabetes in KRV-infected animals. The expression of IL-1beta, TNF-alpha, and IL-12 was significantly decreased in the spleen of AG-treated, KRV-infected DR-BB rats compared with PBS-treated, KRV-infected control rats. Subsequent experiments revealed that AG treatment exerted its preventive effect in KRV-infected rats by maintaining the finely tuned immune balance normally disrupted by KRV, evidenced by a significant decrease in the expression of IFN-gamma, but not IL-4, and a decrease in Th1-type chemokine receptors CCR5, CXCR3, and CXCR4. We also found that iNOS inhibition by AG decreased the KRV-induced expression of MHC class II molecules and IL-2R alpha-...Continue Reading

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Citations

Nov 15, 2006·Diabetes/metabolism Research and Reviews·Nienke van der WerfJan-Luuk Hillebrands
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jae Kwang YooJi-Won Yoon
Oct 19, 2017·Antioxidants & Redox Signaling·Ashley R Burg, Hubert M Tse
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danny ZiprisAldo A Rossini
Sep 26, 2014·Nihon eiseigaku zasshi. Japanese journal of hygiene·Yuji TakedaIchiro Wakabayashi
Aug 22, 2015·Biomolecules·Zachary R Shaheen, John A Corbett
Nov 30, 2006·Annals of the New York Academy of Sciences·Ji-Won Yoon, Hee-Sook Jun
Jan 6, 2009·Annals of the New York Academy of Sciences·F Susan Wong, Li Wen
Feb 3, 2018·International Journal of Biological Macromolecules·Sairong FanXiaoming Chen

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