Immunoresponsiveness in endometriosis: implications of estrogenic toxicants

Environmental Health Perspectives
S E RierJ L Becker

Abstract

Endometriosis is a reproductive disease characterized by the growth of endometrial cells at sites outside the uterus. This disease is a serious disorder associated with chronic pain and infertility, which may be present in 6 million women in this country. Traditional medical therapy has consisted of hormonal regimens that limit the action of endogenous estrogen. The etiology of endometriosis is unknown, but studies suggest that soluble factors known as cytokines play a role in disease pathogenesis. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin) is an environmental toxicant that alters the action of estrogen in reproductive organs and adversely affects immunocompetence. The incidence of endometriosis was determined in rhesus monkeys that were chronically exposed to dioxin for a period of approximately 4 years. Ten years after termination of dioxin treatment, the presence and severity of endometriosis was assessed by surgical laparoscopy. The incidence of endometriosis correlated with dioxin exposure and disease severity was dependent upon the dose administered. Moderate to severe endometriosis was not found in control animals but was documented in three of seven animals exposed to 5 ppt dioxin (43%) and in five of seven an...Continue Reading

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Citations

Apr 6, 2004·Environmental Health Perspectives·Sarah K KeittSherry A Marts
Nov 27, 2002·Medical Hypotheses·D W Bullimore
Sep 16, 2011·The Science of the Total Environment·K Mishra, Ramesh C Sharma
Jan 31, 2004·American Journal of Reproductive Immunology : AJRI·Vikki M AbrahamsGrant R Yeaman
Apr 13, 2002·Annals of the New York Academy of Sciences·Warren G Foster, Sanjay K Agarwal
Apr 29, 2000·Journal of Women's Health & Gender-based Medicine·S G HaynesA P Sassaman
Aug 26, 2019·Reproductive Biology and Endocrinology : RB&E·Hannah M AtkinsDavid L Caudell

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