Immunosenescence-like state is accelerated by constant light exposure and counteracted by melatonin or turmeric administration through DJ-1/Nrf2 and P53/Bax pathways

Journal of Photochemistry and Photobiology. B, Biology
Hanan A El-BakrySafaa S Soliman

Abstract

The awareness of the interrelationship between immunosenescence and constant light exposure can provide new insights into the consequences of excessive exposure to light at night due to light pollution or shift work. Here, we investigated whether constant light exposure (LL) acts as an inducer of immunosenescence. We also determined the role of melatonin or turmeric in reversing the putative effects of constant light and explored for the first time the underlying molecular mechanisms. Young (3-4-month-old) rats were exposed daily to LL alone or in combination with each of melatonin and turmeric for 12 weeks. A group of aged rats (18-months old; n = 6) was used as a reference for natural immunosenescence. Constant light exposure resulted in remarkable pathophysiological alterations resembling those noticed in normal aged rats, manifested as apparent decreases in antioxidant activities as well as Nrf2 and DJ-1 expressions, striking augmentation in oxidative stress, proinflammatory cytokines and expression of TNFα, Bax, and p53 genes, and deleterious changes of lymphoid organs, Co-administration of melatonin or turmeric was able to reverse all alterations induced by LL through upregulation of Nrf2/DJ-1 and downregulation of p53/Ba...Continue Reading

Citations

Sep 23, 2018·Journal of Pineal Research·Rüdiger Hardeland
Jul 10, 2019·Fundamental & Clinical Pharmacology·Zahra Ahmadi, Milad Ashrafizadeh
Mar 14, 2019·International Journal of Molecular Sciences·Rüdiger Hardeland
Apr 20, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Oluwaseun S FaborodeSamuel A Onasanwo

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