Immunosenescence: role and measurement in influenza vaccine response among the elderly

Paul V TargonskiGregory A Poland


Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysfunction may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. Mounting biological evidence supports the potential clinical relevance and impact of immunosenenscence. We briefly review immunosenescence with a focus on replicative senescence in cytotoxic T cells and recent clinical studies examining its association with influenza and infectious disease outcomes.


May 31, 1990·Nature·C B HarleyC W Greider
Feb 1, 1994·Aging : Clinical and Experimental Research·D R JackolaR A Miller
Jun 1, 1996·The Journal of Experimental Medicine·N P WengR J Hodes
Oct 10, 1996·Experimental Cell Research·A G BodnarC P Chiu
Mar 18, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R J LooneyG N Abraham
Mar 25, 1999·Hospital Practice·B F Haynes, L P Hale
Feb 26, 2000·Vaccine·R G Webster
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S C Castle
Oct 24, 2001·Experimental Gerontology·J CampisiM Rubio
Jan 5, 2002·Experimental Gerontology·Raquel TarazonaGraham Pawelec
May 8, 2004·Experimental Gerontology·Karen Suárez KrabbeHelle Bruunsgaard
Jul 23, 2004·Aging Cell·Brian DeVealeLaurent Seroude
Jul 28, 2004·Trends in Immunology·Graham PawelecAnders Wikby
May 11, 2005·Immunological Reviews·Rita B EffrosJanice Man

❮ Previous
Next ❯


Aug 2, 2013·Immunotherapy·Adriana L de AraújoGil Benard
Nov 26, 2010·Annual Review of Medicine·Steven G Deeks
May 14, 2014·Current Opinion in Immunology·Gregory A PolandJames L Kirkland
Jan 30, 2014·Longevity & Healthspan·Daniel BaylisHelen C Roberts
Jun 12, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jian ChenJohn D Mountz
Feb 14, 2009·International Journal of Medical Sciences·Ana LustigDennis D Taub
Jun 10, 2009·Age·Sara Ferrando-MartínezManuel Leal
Oct 29, 2009·Emerging Infectious Diseases·Carline van den DoolJacco Wallinga
Oct 28, 2010·Current Opinion in HIV and AIDS·Guy de Bruyn
Jul 8, 2011·Omics : a Journal of Integrative Biology·Gregory A PolandRobert M Jacobson
Aug 6, 2011·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Nathalie GarçonMarcelle Van Mechelen
Jan 19, 2011·Journal of Clinical Immunology·Christoph R ArnoldBeatrix Grubeck-Loebenstein
Nov 23, 2010·Exercise and Sport Sciences Reviews·Richard J Simpson
Feb 25, 2009·Cancer Immunology, Immunotherapy : CII·Joseph Lustgarten
Feb 26, 2013·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Kamran KhanmoradiJorge A Ortiz
Oct 5, 2007·The New England Journal of Medicine·Kristin L NicholEelko Hak
Jan 28, 2012·International Immunology·Daniela FrascaBonnie B Blomberg
Sep 26, 2012·Expert Review of Vaccines·Nathaniel D LambertGregory A Poland
Oct 7, 2010·Expert Review of Vaccines·Seth J SullivanGregory A Poland
Jul 31, 2008·Expert Review of Vaccines·Hana M El Sahly, Wendy A Keitel
Dec 23, 2015·Biogerontology·Serena MartelliAnis Larbi
Dec 17, 2015·Vaccine·Ana Mosterín HöppingDerek J Smith
Sep 6, 2012·Critical Reviews in Oncology/hematology·Claire FalandryK Lenhard Rudolph
Jul 26, 2011·Brain, Behavior, and Immunity·Guillaume SpielmannRichard J Simpson
Dec 15, 2010·Journal of Pain and Symptom Management·Menahem SassonPesach Shvartzman
Jun 1, 2010·Rheumatic Diseases Clinics of North America·Jorg J GoronzyCornelia M Weyand
Dec 17, 2009·Journal of Comparative Pathology·M J Day
Jul 25, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Daniela WeiskopfBeatrix Grubeck-Loebenstein
Jun 30, 2007·Annals of the New York Academy of Sciences·William B ErshlerZeba S Geloo
Jul 31, 2007·Tissue Antigens·F T Hakim, R E Gress
Nov 19, 2011·Journal of the American Geriatrics Society·Remko EnserinkUNKNOWN Sentinel Surveillance Network on Infectious Diseases in Nursing Homes Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.