Immunostaining for peroxisome proliferator gamma distinguishes dedifferentiated liposarcoma from other retroperitoneal sarcomas

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Andrew E HorvaiRichard J O'Donnell

Abstract

Dedifferentiated liposarcoma can be readily diagnosed by the juxtaposition of a well-differentiated liposarcoma to a nonlipogenic sarcoma. However, if the lipogenic component is not abundant due to surgical sampling or small biopsy, dedifferentiated liposarcoma can be difficult to distinguish from other poorly different sarcomas. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nuclear hormone receptor that plays a critical role in adipocyte differentiation. Prior studies have not only demonstrated PPAR-gamma mRNA in various subtypes of liposarcoma but have also shown that adipocyte differentiation can be induced in some liposarcomas by a PPAR-gamma agonist. In the present study, we investigated whether immunostaining for PPAR-gamma can be used to distinguish dedifferentiated liposarcoma from other retroperitoneal sarcomas. We examined a series of 40 dedifferentiated liposarcoma and compared the staining for PPAR-gamma to a series of 24 retroperitoneal sarcomas that lacked lipogenic differentiation. A monoclonal antibody against PPAR-gamma was used to stain formalin-fixed paraffin-embedded tissue. Specific nuclear immunostaining was present in 37/40 (93%) of the dedifferentiated liposarcoma and 6/24 (25%) of t...Continue Reading

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Citations

Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew E HorvaiFrederic Waldman
Jul 7, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew E HorvaiRichard J O'Donnell
Jan 7, 2009·PPAR Research·Jennifer L Hatton, Lisa D Yee
Mar 21, 2012·The American Journal of Pathology·Masanori HisaokaMitsuhiro Nakamoto
Jul 4, 2009·The American Journal of Surgical Pathology·Lawrance ChungPeiguo G Chu
Mar 13, 2010·The Open Orthopaedics Journal·Takashi TajimaKazuo Mochizuki
Mar 12, 2020·Clinical Sarcoma Research·Anastassia SerguienkoOla Myklebost

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