Immunostimulant and biocompatible gold and silver nanoparticles synthesized using the Ulva intestinalis L. aqueous extract

Journal of Materials Chemistry. B, Materials for Biology and Medicine
N González-BallesterosR Simón-Vázquez

Abstract

This is the first study to report on the biocompatible and immunogenic properties of one-pot synthesised gold and silver nanoparticles (Au@UI and Ag@UI) using the macroalgae Ulva intestinalis (UI). The UI aqueous extract, Au@UI, and Ag@UI were obtained under sterile conditions and fully characterized by UV-vis spectroscopy, TEM, HRTEM, STEM and FTIR spectroscopy. Moreover, for the first time, the composition of carbohydrates in the UI extract has been reported along with the changes observed after nanoparticle synthesis by size exclusion chromatography, in order to investigate their possible role in the biosynthetic process. This study suggested that the polysaccharide fraction of the extract is involved in the formation and stabilization of the nanoparticles. The potential toxicity of the samples was evaluated using different cell lines and the hemocompatibility was tested in mouse erythrocytes. In addition, ROS production, complement activation and cytokine release were evaluated to determine the immunogenicity. The results showed that Au@UI and Ag@UI exhibit good biocompatibility and hemocompatibility, with the exception of Ag@UI nanoparticles at high concentration, which were hemolytic. The samples induced ROS release and c...Continue Reading

References

Sep 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Olga TeufelhoferLeonilla Elbling
Sep 18, 2007·Nature Biotechnology·Sai T ReddyJeffrey A Hubbell
Oct 9, 2009·Molecular Pharmaceutics·Matthew D MassichChad A Mirkin
Jul 27, 2011·Environmental Toxicology and Pharmacology·Eun-Jung ParkKwangsik Park
May 3, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Seyed Davoud JazayeriAbdul Rahman Omar
Jul 26, 2012·Antioxidants & Redox Signaling·Fiorella KotsiasAriel Savina
Sep 14, 2012·Phytotherapy Research : PTR·Anabela AlvesRui L Reis
Oct 2, 2012·Carbohydrate Research·Mehdi TabarsaSangGuan You
Jun 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marina A Dobrovolskaia, Scott E McNeil
Dec 7, 2013·Nature Medicine·Steven G ReedChristopher B Fox
Jan 28, 2014·Current Opinion in Immunology·Ewa Oleszycka, Ed C Lavelle
Mar 29, 2014·Journal of Food and Drug Analysis·Peter P FuHongtao Yu
May 23, 2014·Current Biology : CB·Michael Schieber, Navdeep S Chandel
Aug 26, 2014·European Journal of Medicinal Chemistry·Jayachandra Reddy NakkalaSudha Rani Sadras
Apr 16, 2015·Journal of Immunotoxicology·Micah KingstonRichard Brey
May 3, 2015·International Journal of Biological Macromolecules·Xue-Qiang ZhaJian-Ping Luo
Jun 6, 2015·Materials Science & Engineering. C, Materials for Biological Applications·J UpadhyayA K Buragohain
Jun 7, 2015·Biotechnology Advances·Ana Sara CordeiroMaría de la Fuente
Jul 8, 2015·Saudi Journal of Biological Sciences·Marijana KosanićTatjana Stanojković
May 24, 2016·International Journal of Biological Macromolecules·Napassorn PeasuraLouis Kuoping Chao
Aug 19, 2016·International Journal of Nanomedicine·Vahid AsgaryReza Ahangari Cohan
Dec 6, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Dandan WangDeok Chun Yang
Mar 1, 2017·Colloids and Surfaces. B, Biointerfaces·N González-BallesterosM C Rodríguez-Argüelles
Mar 16, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Veronika SoshnikovaDeok Chun Yang
Apr 30, 2017·Chemical Science·Lev A Dykman, Nikolai G Khlebtsov
Oct 4, 2017·Current Opinion in Immunology·Ross M Kedl, Robert Seder
Dec 19, 2017·Trends in Immunology·Michelle L BookstaverChristopher M Jewell
Jan 15, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Valentina GalbiatiEmanuela Corsini
Feb 13, 2018·Food Research International·C AfonsoN M Bandarra
Feb 18, 2018·Journal of Nanobiotechnology·Khwaja Salahuddin SiddiqiRifaqat A K Rao
Feb 18, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jean-Baptiste Coty, Christine Vauthier
Mar 4, 2018·Scientific Reports·Zsófia MolnárIstván Lagzi
Mar 30, 2018·Current Opinion in Biotechnology·Steven FreyRavi S Kane
Apr 21, 2018·Talanta·Narges ElahiMohammad Hadi Baghersad
May 5, 2018·Frontiers in Immunology·Mercedes PeleteiroÁfrica González-Fernández
May 31, 2018·Journal of Photochemistry and Photobiology. B, Biology·Mona HamelianHojat Veisi

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Citations

Sep 27, 2019·Current Pharmaceutical Design·Romina MitarotondaMauricio C De Marzi
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·N González-BallesterosR Simón-Vázquez
May 24, 2021·International Journal of Biological Macromolecules·N González-BallesterosH Domínguez
Aug 1, 2021·Journal of Biomedical Materials Research. Part a·Feiyang CaiXing Jiang
Aug 20, 2021·Critical Reviews in Food Science and Nutrition·Lucía CassaniAndrea Gomez-Zavaglia

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Methods Mentioned

BETA
size exclusion chromatography
Assay
flow cytometry
PMA
density gradient centrifugation
surface plasmon resonance
X-ray

Software Mentioned

Digital Micrograph
GraphPad Prism
Image [UNK]

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