Immunostimulant patch enhances immune responses to influenza virus vaccine in aged mice.

Journal of Virology
Mimi Guebre-XabierGregory M Glenn

Abstract

Improvement in the immune response to influenza virus vaccination in the elderly represents the primary unmet need in influenza virus vaccination. We have shown that topical application of immunostimulating (IS) patches containing heat-labile enterotoxin of Escherichia coli (LT) enhances immune responses to injected vaccines. We extend these findings and show that LT-IS patch application enhances the antibody responses to influenza virus vaccination in both young and aged mice. LT-IS patches markedly increased influenza virus-specific immunoglobulin G (IgG), hemagglutination inhibition antibody, mucosal antibody, and T-cell responses. The magnitude of the immune responses in aged mice receiving an LT-IS patch was equivalent to or greater than that of the immune responses in young mice given vaccine alone. These results suggest that addition of an LT-IS patch may compensate for the deficient immune function seen in the aged in response to influenza virus vaccination. Therefore, use of an LT-IS patch could be a new, safe, and simple immunization strategy that may significantly improve the outcome of influenza virus vaccination in the elderly.

References

Feb 1, 1979·The Journal of Infectious Diseases·B J FeeryE I Morrison
Mar 1, 1985·The Journal of Experimental Medicine·G Schuler, R M Steinman
Oct 20, 1969·JAMA : the Journal of the American Medical Association·D J D'AlessioE C Dick
Dec 1, 1980·American Journal of Epidemiology·W H Barker, J P Mullooly
Oct 1, 1995·Annals of Internal Medicine·P A GrossR A Levandowski
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·M RescignoP Ricciardi-Castagnoli
Feb 26, 2000·Vaccine·R G Webster
Oct 16, 2001·European Journal of Epidemiology·E CrocettiE Buiatti
Jan 5, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·S A HammondG M Glenn
Mar 16, 2002·Infection and Immunity·Fernando Güereña-BurgueñoGregory M Glenn
May 23, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James R SmithEdward L Schneider
Aug 21, 2002·The Journal of Experimental Medicine·F GeissmannJ Davoust
Apr 4, 2003·The New England Journal of Medicine·Kristin L NicholMarika Iwane
Apr 18, 2003·Clinical and Experimental Immunology·M CumberbatchC E M Griffiths
Feb 3, 2004·Immunology and Allergy Clinics of North America·Gregory M GlennLarry R Ellingsworth
Feb 27, 2004·The New England Journal of Medicine·Margot MutschRobert Steffen

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Citations

Oct 27, 2007·DNA and Cell Biology·Mikayel MkrtichyanDavid H Cribbs
Jan 1, 2010·Annual Review of Chemical and Biomolecular Engineering·Pankaj Karande, Samir Mitragotri
Aug 24, 2010·Journal of Translational Medicine·Jochen T SchaeferCraig L Slingluff
Jan 6, 2012·The Journal of Investigative Dermatology·Danuta Gutowska-Owsiak, Graham S Ogg
Oct 5, 2007·Comparative Immunology, Microbiology and Infectious Diseases·Behazine Combadière, Brice Mahé
Jun 30, 2007·Annals of the New York Academy of Sciences·William B ErshlerZeba S Geloo
Apr 3, 2014·Journal of Clinical Pharmacology·Anne N Nafziger, David S Pratt
May 17, 2006·Veterinary Immunology and Immunopathology·E FingerutJ Pitcovski
Jan 19, 2012·Human Vaccines & Immunotherapeutics·Philip R DormitzerGiuseppe Del Giudice
Jan 7, 2014·Clinical and Vaccine Immunology : CVI·Wing Ki ChengJan P Dutz

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