Immunostimulants for malignant gliomas

Neurosurgery Clinics of North America
Nicholas Butowski

Abstract

Several immunostimulant approaches have been studied in the treatment of gliomas. The advent of recombinant DNA technology led to a nonspecific immunostimulation via systemic administration of cytokines. Recently, in attempts to more closely mimic their natural activity, cytokines have been delivered by implanting genetically transduced cells or by using in vivo gene transfer techniques. The latest efforts have focused on immunostimulatory agents that act directly on antigen-presenting cells and effector cells of the immune system via pattern recognition receptors. Combining these strategies with more than one mode of immunotherapy may provide better clinical results.

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Citations

Dec 23, 2011·Clinical & Developmental Immunology·Christopher JacksonMichael Lim
Sep 23, 2011·Genes and Immunity·J T TossbergT M Aune
Jan 17, 2012·Expert Opinion on Drug Delivery·José Vicente González-AramundizNoemi Csaba
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Jun 4, 2015·Journal of Neuro-oncology·Joseph P AntoniosLinda M Liau
Jul 31, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mingjie QingLijuan Cheng

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