Immunostimulants revisited: focus on the pharmacology of Ribomunyl

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Pierre Portalès, J Clot

Abstract

Ribomunyl is an immunostimulant that was developed and commercialized in the 1980s in France and has subsequently been made available in a large number of countries. The formulation is composed of proteoglycans from Klebsiella pneumoniae and of ribosomes from four of the most commonly encountered bacterial strains in recurrent respiratory tract infections. While it is obviously difficult to present a thorough summary of all historical data, here we revisit the mode of action of this immunostimulant and present a perspective in the context of the most recent data and hypotheses on the mechanisms of the antibacterial immune responses. We provide various examples of these mechanisms in innate immunity (phagocytosis, cell adhesion, dendritic cell maturation, Toll-like receptors, interferon production, proinflammatory cytokines, activation of natural killer cells), as well as in adaptative immunity (polyclonal activation of T and B cells, specific immunoglobulin A immune response in an integrated view of the mucosal immune system, and T helper type 1/type 2 [Th1/Th2] regulation and balance). The effect of this immunostimulant on anti-infectious responses can be explained, not only by a stimulation of the antibacterial defense direct...Continue Reading

References

Jan 1, 1991·International Journal of Immunopharmacology·C RoquesD Levy
Jan 1, 1990·International Journal of Immunopharmacology·G C FaureA Quantain
Nov 1, 1994·FEMS Immunology and Medical Microbiology·C ZaninG C Faure
Nov 1, 1993·Scandinavian Journal of Immunology·M C BénéG C Faure
Mar 1, 1997·International Journal of Immunopharmacology·M N Kolopp-SardaG C Faure
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·E SerranoP Van Cauwenberge
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J P Kraehenbuhl, M R Neutra
Apr 2, 2002·Journal of Immunotherapy·Claire BoccaccioAlessandra Nardin
Apr 16, 2002·Science·Ruslan Medzhitov, Charles A Janeway
Apr 17, 2002·International Journal of Pediatric Otorhinolaryngology·R MoraM P Cordone
Sep 23, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Joseph BellantiElie Serrano
Oct 14, 2003·Trends in Immunology·Paul J HertzogJohn A Hamilton
Sep 30, 2004·Nature Immunology·Kasper HoebeBruce Beutler
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marco Rossi, James W Young
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·P BoyleC Robertson

❮ Previous
Next ❯

Citations

Aug 10, 2012·Folia Microbiologica·Dana CechovaLudmila Prokesova
Jan 7, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Renzo MoraAngelo Salami
Apr 14, 2012·Acta Oto-laryngologica·Renzo MoraGiorgio Peretti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.