Immunostimulatory activity of Milife, a novel immunomodulator of fungus origin

Immunopharmacology and Immunotoxicology
N Y ViskovaV I Dizha

Abstract

Milife is a novel immunomodulator derived from the fungus Fusarium Sambucium. In this study we examined immunomodulatory properties of Milife in 10 months-old BLRB mice. Milife was given to mice orally in a daily dose of 1 mg per mouse, for 2 to 6 days. Groups of mice were sacrificed on days 2, 4, and 6 of treatment, and 3 weeks after completion of a 6 days treatment with Milife, and lymphoid organs were obtained for analysis. Milife administration led to rapid and significant increase in total leukocyte and lymphocyte numbers in peripheral blood that persisted for at least 3 weeks after a 6 days treatment. Cellularity of lymph nodes, bone marrow and thymus increased significantly at days 4 and 6 of treatment, but returned to pretreatment levels after Milife discontinuation. Though total splenocyte numbers did not change dramatically, there occurred delayed increase in CD4+ cells in the spleen 3 weeks following treatment. Preferential accumulation of CD4+ cells was also consistently found in peripheral blood, with the peak being observed at day 6 of treatment. As a result, CD4/CD8 ratio in blood and spleen was significantly higher in treated than in untreated mice. Splenocytes from treated mice proliferated more vigorously in r...Continue Reading

References

Feb 1, 1992·International Journal of Immunopharmacology·I M DozmorovR V Petrov
Feb 1, 1995·Bioscience Reports·R V PetrovL A Fonina
May 1, 1994·Immunopharmacology and Immunotoxicology·I M DozmorovV T Ivanov
Sep 1, 1996·The American Journal of Medicine·B J Brew, J Miller
Jan 1, 1997·International Archives of Allergy and Immunology·C MoserH H Peter

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Citations

Apr 29, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E L VodovozovaJ G Molotkovsky

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