Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice

The Journal of Allergy and Clinical Immunology
Sook Young LeeDavid H Broide

Abstract

Airway remodeling in asthma is associated with angiogenesis. We have examined whether immunostimulatory sequences of DNA (ISSs) inhibit allergen-induced airway angiogenesis and expression of angiogenic cytokines in a mouse model of airway remodeling. Mice sensitized to ovalbumin were challenged repetitively with ovalbumin for three months to develop airway remodeling and angiogenesis. Levels of angiogenesis were compared in ISS-treated and control mice. Mice challenged with ovalbumin developed significantly increased levels of peribronchial angiogenesis (increase in the number of CD31+ peribronchial small blood vessels) and an increase in the peribronchial vascular area as assessed by image analysis. Ovalbumin-induced peribronchial angiogenesis was associated with increased bronchoalveolar lavage levels of vascular endothelial growth factor (VEGF) and an increase in the number of peribronchial cells expressing VEGF. Treatment of mice with ISS before repetitive ovalbumin challenge significantly reduced the levels of peribronchial angiogenesis as well as the levels of bronchoalveolar lavage VEGF and the number of peribronchial cells expressing VEGF. ISS is unlikely to act directly on endothelial cells to inhibit angiogenesis beca...Continue Reading

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Citations

Oct 12, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Marina MillerDavid H Broide
Feb 5, 2011·International Archives of Allergy and Immunology·Chin Kook RheeSook Young Lee
Oct 31, 2009·American Journal of Respiratory and Critical Care Medicine·Janette K BurgessBrian G Oliver
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Mar 11, 2008·The Journal of Allergy and Clinical Immunology·David H Broide
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Nov 6, 2020·Inflammopharmacology·Madhur D ShastriPhilip M Hansbro

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