Immunostimulatory effect of laminarin on RAW 264.7 mouse macrophages.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Ji Young LeeWansu Park

Abstract

This study investigated the immunostimulatory effects of laminarin with respect to inflammatory mediators such as hydrogen peroxide, calcium, nitric oxide, various cytokines, transcription factors, and immune response gene in RAW 264.7 mouse macrophages. Laminarin did not reduce the cell proliferation of RAW 264.7 mouse macrophages at concentrations up to 500 µg/mL. Laminarin significantly increased the release of hydrogen peroxide, calcium, nitric oxide, monocyte chemotactic protein-1, vascular endothelial growth factor, leukemia inhibitory factor, and granulocyte-colony stimulating factor with enhancing expression of Signal Transducer and Activator of Transcription 1 (STAT1), STAT3, c-Jun, c-Fos, and cyclooxygenase-2 mRNA in RAW 264.7 cells. The results suggest that laminarin has immunostimulatory properties, strengthening immune reactions via the transcription factor pathway in macrophages.

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Citations

Feb 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tung-Ho WuChih-Chuang Liaw
Jan 20, 2016·International Journal of Biological Macromolecules·Xiaocheng LvLeshuai W Zhang
Nov 26, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Mi-Hye So, You-Kyung Choi
Sep 8, 2017·International Journal of Molecular Sciences·Patrícia de Souza Bonfim-MendonçaTerezinha Inez Estivalet Svidzinski
Sep 6, 2017·The Journal of Pharmacy and Pharmacology·Somanjana Khatua, Krishnendu Acharya
Sep 11, 2018·Critical Reviews in Biotechnology·Ilekuttige Priyan Shanura FernandoYou-Jin Jeon
Aug 22, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu Bin JiHe Zhang
Oct 3, 2018·The Journal of Reproduction and Development·Xuerui YaoNam-Hyung Kim
Apr 26, 2014·Oncology Letters·Chen-Feng Ji, Yu-Bin Ji
Mar 22, 2020·Marine Drugs·Ana DobrinčićVerica Dragović-Uzelac
Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Gabbia, Sara De Martin
Jul 11, 2018·Marine Drugs·Ariana A Vasconcelos, Vitor H Pomin
Aug 7, 2019·Biomolecules·Nina Sanina
Nov 17, 2020·Critical Reviews in Food Science and Nutrition·Ravindra Pal SinghJagan Mohan Rao Tingirikari
Jan 19, 2020·Carbohydrate Polymers·Mehrzad ZargarzadehJoão F Mano
Nov 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Bhakti Tanna, Avinash Mishra
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Enver KeleszadeAdele Costabile
May 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Bhakti Tanna, Avinash Mishra
Jul 3, 2021·Marine Drugs·Emer ShannonMaria Hayes
Mar 7, 2020·Chemical Research in Toxicology·Mariana ColaçoOlga Borges

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Methods Mentioned

BETA
cytokine assay
Assay

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