Abstract
This study investigated the immunostimulatory effects of laminarin with respect to inflammatory mediators such as hydrogen peroxide, calcium, nitric oxide, various cytokines, transcription factors, and immune response gene in RAW 264.7 mouse macrophages. Laminarin did not reduce the cell proliferation of RAW 264.7 mouse macrophages at concentrations up to 500 µg/mL. Laminarin significantly increased the release of hydrogen peroxide, calcium, nitric oxide, monocyte chemotactic protein-1, vascular endothelial growth factor, leukemia inhibitory factor, and granulocyte-colony stimulating factor with enhancing expression of Signal Transducer and Activator of Transcription 1 (STAT1), STAT3, c-Jun, c-Fos, and cyclooxygenase-2 mRNA in RAW 264.7 cells. The results suggest that laminarin has immunostimulatory properties, strengthening immune reactions via the transcription factor pathway in macrophages.
References
Feb 5, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·N Pugh, D S Pasco
Jan 24, 2006·International Immunopharmacology·Igor A Schepetkin, Mark T Quinn
Jul 20, 2007·Antioxidants & Redox Signaling·Joseph Cuschieri, Ronald V Maier
Oct 9, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Wansu ParkSeong Kyu Park
Jul 7, 2009·Journal of Ethnopharmacology·Seok-Bin YoonWansu Park
Sep 11, 2009·The Journal of Clinical Investigation·Jenelle M TimminsIra Tabas
Sep 16, 2009·Annals of the New York Academy of Sciences·Ira TabasWahseng Lim
Apr 15, 2010·Life Sciences·Soo Kyung LeeHyeon Soo Kim
Jun 22, 2010·Phytotherapy Research : PTR·Sang-Suk YukWansu Park
Jul 6, 2010·Phytochemistry·Laurie-Eve RiouxMartin Beaulieu
Oct 14, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ji Young Lee, Wansu Park
Dec 14, 2011·Toxicology Letters·Ji Young LeeDong Kee Yi
Citations
Dec 4, 2012·Nutrients·Hye Kyung KimWansu Park
Feb 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tung-Ho WuChih-Chuang Liaw
Sep 18, 2014·Journal of Medicinal Food·Jae-Ho ChoiDeog-Hwan Oh
Sep 24, 2015·Marine Drugs·Bruno GügiMuriel Bardor
Mar 22, 2016·Environmental Science. Nano·Sean E LehmanSarah C Larsen
Jan 20, 2016·International Journal of Biological Macromolecules·Xiaocheng LvLeshuai W Zhang
Nov 26, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Mi-Hye So, You-Kyung Choi
Mar 11, 2017·PloS One·Naomi M WalshChristina M Hull
Mar 16, 2017·Bioconjugate Chemistry·Aline MongisVéronique Piller
Sep 8, 2017·International Journal of Molecular Sciences·Patrícia de Souza Bonfim-MendonçaTerezinha Inez Estivalet Svidzinski
Sep 6, 2017·The Journal of Pharmacy and Pharmacology·Somanjana Khatua, Krishnendu Acharya
Sep 11, 2018·Critical Reviews in Biotechnology·Ilekuttige Priyan Shanura FernandoYou-Jin Jeon
Aug 22, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu Bin JiHe Zhang
Sep 18, 2014·PloS One·Patricia de Souza Bonfim-MendonçaTerezinha Inez Estivalet Svidzinski
Oct 3, 2018·The Journal of Reproduction and Development·Xuerui YaoNam-Hyung Kim
Feb 13, 2019·Marine Drugs·Xueqian Zhang, Marianne Thomsen
Jul 3, 2019·Nutrients·Qing HuangZhao Wang
Apr 21, 2017·Oncotarget·Kyeongeun SongJun-O Jin
Jun 4, 2020·Marine Drugs·Natalya N BesednovaSvetlana P Ermakova
Apr 26, 2014·Oncology Letters·Chen-Feng Ji, Yu-Bin Ji
Jun 27, 2019·Current Pharmaceutical Design·Jun LiGuangli Yu
Mar 22, 2020·Marine Drugs·Ana DobrinčićVerica Dragović-Uzelac
Apr 28, 2018·Viruses·Young-Jin KimWansu Park
Sep 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Gabbia, Sara De Martin
Jul 11, 2018·Marine Drugs·Ariana A Vasconcelos, Vitor H Pomin
Aug 7, 2019·Biomolecules·Nina Sanina
Nov 17, 2020·Critical Reviews in Food Science and Nutrition·Ravindra Pal SinghJagan Mohan Rao Tingirikari
Jan 19, 2020·Carbohydrate Polymers·Mehrzad ZargarzadehJoão F Mano
Nov 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Bhakti Tanna, Avinash Mishra
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Enver KeleszadeAdele Costabile
Dec 30, 2020·Marine Drugs·Haowei ZhongXiao Han
May 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Bhakti Tanna, Avinash Mishra
May 30, 2021·Scientific Reports·Hyun-Ju KimWansu Park
Jul 3, 2021·Marine Drugs·Emer ShannonMaria Hayes
Mar 7, 2020·Chemical Research in Toxicology·Mariana ColaçoOlga Borges
Oct 12, 2021·Homeopathy : the Journal of the Faculty of Homeopathy·Oskan TasinovDiana Ivanova