Immunostimulatory effect of Zinc Phthalocyanine derivatives on macrophages based on the pro-inflammatory TNFα and IL1β cytokine production levels

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Furkan AyazMine Ince

Abstract

In this study, we examined the effect of halogen substitution on the ability of ZnPcs to stimulate or regulate the immune system cells. There have been studies focusing on the usage of Pcs as treatment option against different cancer types. More attention should be paid on their possible positive or negative effects on the immune system for better prognosis rates. We designed and synthesized unique ZnPcs with iodine substitution and further tested their effect on mammalian macrophage cell line. Macrophages are crucial cell types that can define the immune response by cytokine production as well as by antigen presentation to the other immune system cells after phagocytosis of the danger associated molecules. Our results suggest an immunostimulatory role for the iodine substituted ZnPc on macrophages based on the changes in pro-inflammatory cytokine production levels (TNFα, IL1β and IL6). This effect dependent on the presence of iodine; since non-substituted ZnPc did not exert such a stimulatory activity on the macrophages. These results support a possible use of the reagents against the tumor types that would get affected detrimentally by the pro-inflammatory environment.

Citations

Feb 20, 2019·Molecular Biology Reports·Furkan AyazRükan Genç
Dec 20, 2019·Applied Biochemistry and Biotechnology·Furkan AyazKasim Ocakoglu
Mar 19, 2020·Photodiagnosis and Photodynamic Therapy·Harika Topal ÖnalFurkan Ayaz

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