Mar 1, 1976

Immunosuppressant activity of the ansamycins

Antimicrobial Agents and Chemotherapy
J E KasikJ S Thompson

Abstract

The immunosuppressive effect of four analogues of rifampin and two streptovaracins on cell-mediated immunity has been determined. Tuberculin hypersensitivity in the footpads of immunized mice was inhibited by three of the rifampin analogues and by both streptovaracins. The observed in vivo immunosuppressive activity of the compounds tested was not correlated with their in vitro activity against mycobacterial growth but was associated with their toxicity in mice. These data indicate that some of the analogues of rifampin and the streptovaracins can significantly suppress cell-mediated immunity and suggest that other ansamycins may have significant immunosuppressant activity.

  • References9
  • Citations6

Mentioned in this Paper

Streptovaricin
Tubocin
Mycobacterium tuberculosis H37Rv
PPD-L
Delayed Hypersensitivity
Mice, Inbred Strains
Cellular Immune Response
Immunosuppressive Agents

About this Paper

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.