Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

Brain Research
L J MoiaO Hatase

Abstract

Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphocytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.

References

Jan 1, 1992·Annual Review of Immunology·N H Sigal, F J Dumont
Feb 1, 1991·Brain Research. Molecular Brain Research·R P LadD C Hilt
Jan 1, 1989·Advances in Experimental Medicine and Biology·H MatsuiO Hatase
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
May 14, 1993·Biochemical and Biophysical Research Communications·M AsamiC Tanaka

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Citations

Sep 24, 1999·Journal of Neuroscience Research·J C McEachern, C A Shaw
May 15, 1996·European Journal of Pharmacology·C ToberR Bartsch
Sep 6, 2003·Pharmacology, Biochemistry, and Behavior·Amanpreet SinghShrinivas K Kulkarni
Oct 9, 1999·Epilepsy Research·I BlümckeO D Wiestler
Jan 21, 2014·Biochemical and Biophysical Research Communications·Francisco J MuñozNibaldo C Inestrosa
Mar 3, 2011·Neuroscience Letters·Teresa RavizzaAnnamaria Vezzani
Nov 13, 2007·Progress in Neurobiology·Ashakumary LakshmikuttyammaRajendra K Sharma
Nov 11, 2006·Epilepsy Research·Zuzanna Setkowicz, Małgorzata Ciarach
Dec 13, 2005·Journal of Neurochemistry·Ashakumary LakshmikuttyammaRajendra K Sharma
Oct 9, 2003·The Journal of Urology·Kunihiro NozakiHideki Matsui
May 17, 2008·CNS Neuroscience & Therapeutics·Germán Sierra-Paredes, Germán Sierra-Marcuño
Nov 25, 2003·The Journal of Biological Chemistry·Hai-Yan WuHideki Matsui
Jan 13, 2015·International Journal of Neurology & Brain Disorders·John N CampbellSevern B Churn
Aug 12, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carmen Freire-CoboGermán Sierra-Marcuño
May 2, 2001·The International Journal of Biochemistry & Cell Biology·C SolàJ Serratosa
Oct 13, 2006·Science's STKE : Signal Transduction Knowledge Environment·James O McNamaraA Soren Leonard

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