Immunosuppressants and risk of Parkinson disease

Annals of Clinical and Translational Neurology
Brad A RacetteSusan Searles Nielsen

Abstract

We performed a population-based case-control study of United States Medicare beneficiaries age 60-90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use of immunosuppressants. Inosine monophosphate dehydrogenase inhibitors (relative risk = 0.64; 95% confidence interval 0.51-0.79) and corticosteroids (relative risk = 0.80; 95% confidence interval 0.77-0.83) were both associated with a lower risk of Parkinson disease. Inverse associations for both remained after applying a 12-month exposure lag. Overall, this study provides evidence that use of corticosteroids and inosine monophosphate dehydrogenase inhibitors might lower the risk of Parkinson disease.

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Citations

Aug 23, 2019·Statistics in Medicine·Martijn J SchuemieGeorge Hripcsak
Oct 15, 2019·Journal of Parkinson's Disease·Bryan Killinger, Viviane Labrie
Jul 10, 2020·JCI Insight·Kyle S ConwaySriram Venneti
Mar 13, 2020·Frontiers in Immunology·Oluwaseun FatobaToshihide Yamashita
Apr 26, 2020·Nature Reviews. Neurology·Eng-King TanJoseph Jankovic
Oct 20, 2018·Frontiers in Neurology·Kirsten M ScottCaroline H Williams-Gray
Dec 26, 2018·Journal of Parkinson's Disease·Honglei Chen, Beate Ritz
Aug 2, 2019·Acta neurologica Belgica·G KenangilF M Domac
Dec 2, 2020·Journal of Translational Medicine·Fu-Chiang YehTse-Yen Yang
Feb 2, 2020·Brain, Behavior, and Immunity·Ruwani S WijeyekoonCaroline H Williams-Gray
Feb 13, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Tai WangYuming Xu
Feb 16, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Stellina Y H LeeSusannah J Tye
Oct 22, 2018·Trends in Neurosciences·Michaela E JohnsonPatrik Brundin
May 26, 2021·Molecular Neurobiology·Benjamin RosenSimon Geir Møller
Jun 3, 2021·International Journal of Molecular Sciences·Johan Wallin, Per Svenningsson
Jan 19, 2021·Neuro-degenerative Diseases·Alejandra Camacho-SotoSusan Searles Nielsen
Jan 16, 2022·Brain, Behavior, and Immunity·Akua A KarikariChi Wang Ip
Feb 4, 2022·Internal Medicine·Hidetomo MurakamiYasuyuki Iguchi

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