The success of sirolimus and low-dose tacrolimus in islet cell transplantation has influenced many transplant centers to utilize this novel regimen. The long-term safety and tolerability of this steroid-free immunosuppressive protocol for allogeneic islet transplantation has yet to be determined. We transplanted 26 adult patients with long standing type 1 diabetes mellitus between April 2000 and June 2004. Immunosuppression consisted of induction with daclizumab and maintenance therapy with tacrolimus and sirolimus. Adverse events (AEs) in patients were followed and graded using the Common Terminology Criteria for Adverse Events, version 3.0 (National Cancer Institute). To date, the majority of patients were able to remain on the immunosuppression combination for up to 22+/-11 months. Four patients were successfully converted to Mycophenolate Mofetil due to tacrolimus-related toxicity. Withdrawal from immunosuppression was decided in four patients due to hypereosinophilic syndrome, parvovirus infection, aspiration pneumonia, and severe depression, respectively. Six patients required filgrastim therapy for neutropenia. Transient elevation of liver enzymes was observed in most patients early after islet infusion. Increased LDL in...Continue Reading
Rapid tightening of blood glucose control leads to transient deterioration of retinopathy in insulin dependent diabetes mellitus: the Oslo study
OKT3 treatment for allograft rejection is a risk factor for cytomegalovirus disease in liver transplantation
Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. Diabetes Control and Complications Trial Research Group
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
Switch from cyclosporine A to tacrolimus in renal transplant recipients: impact on Th1, Th2, and monokine responses
Aseptic meningitis due to administration of intravenous immunoglobulin with an unusually high number of leukocytes in cerebrospinal fluid
Toward further expansion of the organ pool for adult liver recipients: splitting the cadaveric liver into right and left lobes
Achievement of insulin independence in three consecutive type-1 diabetic patients via pancreatic islet transplantation using islets isolated at a remote islet isolation center
Prospective, randomized, multi-center trial of antibody induction therapy in simultaneous pancreas-kidney transplantation
Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience
The impact of sirolimus, mycophenolate mofetil, cyclosporine, azathioprine, and steroids on wound healing in 513 kidney-transplant recipients
Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes
Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody
Problems in postoperative renal transplant recipients who present to the emergency unit: experience at one center
Use of D-STAT to prevent bleeding following percutaneous transhepatic intraportal islet transplantation
Assessment of the severity of hypoglycemia and glycemic lability in type 1 diabetic subjects undergoing islet transplantation
Achievement of insulin independence via pancreatic islet transplantation using a remote isolation center: a first-year review
Cytomegalovirus prevalence and transmission after islet allograft transplant in patients with type 1 diabetes mellitus
Immunosuppressive level and other risk factors for basal cell carcinoma and squamous cell carcinoma in heart transplant recipients
Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience
No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation
Improved metabolic control and quality of life in seven patients with type 1 diabetes following islet after kidney transplantation
Intraperitoneal insulin infusion versus islet transplantation: comparative study in patients with type 1 diabetes
Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanercept.
Oleanolic Acid, a plant triterpenoid, significantly improves survival and function of islet allograft.
Microfabricated nanochannel implantable drug delivery devices: trends, limitations and possibilities
The Influence of Stabilized Deconjugated Ursodeoxycholic Acid on Polymer-Hydrogel System of Transplantable NIT-1 Cells.
Immunomodulation by blockade of the TRANCE co-stimulatory pathway in murine allogeneic islet transplantation.
Combined islet and hematopoietic stem cell allotransplantation: a clinical pilot trial to induce chimerism and graft tolerance
Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol
Blockade of RAGE suppresses alloimmune reactions in vitro and delays allograft rejection in murine heart transplantation
Use of low dose tacrolimus, mycophenolate mofetil and maintenance IL-2 receptor blockade in an islet transplant recipient
Patient-reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: a systematic review.
Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression
Infectious complications of pancreatic islet transplantation: clinical experience and unanswered questions
Resolution of neurotoxicity and beta-cell toxicity in an islet transplant recipient following substitution of tacrolimus with MMF
Long-term metabolic and hormonal effects of exenatide on islet transplant recipients with allograft dysfunction
Human amniotic epithelial cells induce localized cell-mediated immune privilege in vitro: implications for pancreatic islet transplantation
Coronary artery calcium may stabilize following islet cell transplantation in patients with type 1 diabetes
Mizoribine as sole immunosuppressive agent in islet xenotransplantation models: a candidate immunosuppressant causing no adverse effects on islets
Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions
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The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.
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