Immunosuppression by breast cancer associated p43-effect of immunomodulators

Breast Cancer Research and Treatment
H R RosenC Moroz

Abstract

It has been previously shown that p43- a breast cancer associated antigen-has immunosuppressive properties. The present study was carried out in order to elucidate the pathomechanisms of immunosuppression in breast cancer patients influenced by the expression of p43. Lymphocytes were cultured from blood of 29 women with benign lesions in the breast as well as from 41 female patients with breast cancer. Lymphocyte stimulation was performed by addition of Concanavalin (Con A) in cultures with lymphocytes alone (CONLYM) or in lymphocytes incubated with p43 (CONAg). In other series immunomodulation was tried by addition of indomethacin (INDLYM, INDAg), levamisole (LEVLYM, LEVAg), or interleukin-2 (ILLYM, ILAG). In breast cancer patients, addition of p43 significantly inhibited the activation of lymphocyte proliferation by Con A compared to women with benign tumors. The addition of indomethacin or levamisole did not influence this inhibitory effect of p43 in breast cancer patients. Contrary to these observations, addition of IL-2 resulted in increased proliferation of lymphocytes from patients with benign as well as malignant tumors, which was inhibited after addition of p43. Analysis of the correlation of the immunosuppressive prop...Continue Reading

References

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Sep 1, 1988·Scandinavian Journal of Immunology·R HalvorsenE Thorsby
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Citations

May 7, 1999·International Journal of Immunopharmacology·J W Hadden
Mar 28, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Muzammal HussainMuhammad Mahmood Mukhtar

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