Jan 1, 1976

Immunosuppression by fetal liver as a model for tolerance to self

Advances in Experimental Medicine and Biology
T Umiel

Abstract

The embryonic liver chimera system was used as a model to study the development of tolerance to self antigens. It was found that the permanent tolerant state which was induced in (C3H/eb x C57BL/6)F1 irradiated hosts following reconstitution with parental C57BL liver cells could be due to the development of suppressor cells within the liver cell inoculum, which specifically prevent reactivity of immunocompetent cells. General suppressor activity could be found in embryonic liver cells at early stages of gestation. However, the differentiation of such cells into specific suppressor of "self" antigens is dependent on the presence of the thymus.

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Mentioned in this Paper

Embryo
Decreased Immunologic Activity [PE]
C57BL/6 Mouse
Neoplasm of Uncertain or Unknown Behavior of Thymus
Chimera Organism
Disease of Thymus Gland
Graft Vs Host Reaction
Thymic Tissue
Lymphocyte Activation
Mice, Inbred C3H

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