Immunosuppression: evolution in practice and trends, 1994-2004

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
H-U Meier-KriescheA B Leichtman

Abstract

Over the last 10 years, there have been important changes in immunosuppression management and strategies for solid-organ transplantation, characterized by the use of new immunosuppressive agents and regimens. An organ-by-organ review of OPTN/SRTR data showed several important trends in immunosuppression practice. There is an increasing trend toward the use of induction therapy with antibodies, which was used for most kidney, pancreas after kidney (PAK), simultaneous pancreas-kidney (SPK) and pancreas transplant alone (PTA) recipients in 2004 (72-81%) and for approximately half of all intestine, heart and lung recipients. The highest usage of the tacrolimus/mycophenolate mofetil combination as discharge regimen was reported for SPK (72%) and PAK (64%) recipients. Maintenance of the original discharge regimen through the first 3 years following transplantation varied significantly by organ and drug. The usage of calcineurin inhibitors for maintenance therapy was characterized by a clear transition from cyclosporine to tacrolimus. Corticosteroids were administered to the majority of patients; however, steroid-avoidance and steroid-withdrawal protocols have become increasingly common. The percentage of patients treated for acute re...Continue Reading

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References

Jul 6, 2000·Immunopharmacology·T S Mele, P F Halloran
Jul 12, 2002·Drugs·Maria L Raimondo, Andrew K Burroughs
Jan 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Roberto J FirpiGary L Davis
Jan 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Satheesh NairGeorge Loss
Sep 25, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John C BucuvalasUNKNOWN Studies of Pediatric Liver Transplantation Research Group
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ron ShapiroAlan B Leichtman
Jun 24, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Russell H WiesnerJohn R Lake
Apr 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G N LevineD E Schaubel

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Citations

Aug 21, 2007·Molecular Diagnosis & Therapy·Mercè BrunetOlga Millán
Sep 20, 2012·Applied Microbiology and Biotechnology·Miriam Martínez-CastroCarlos Barreiro
Nov 8, 2008·International Urology and Nephrology·Ramesh SaxenaXin J Zhou
Sep 26, 2009·International Urology and Nephrology·Adam RemportIstvan Mucsi
Jan 9, 2010·International Urology and Nephrology·Adam RemportMiklos Zsolt Molnar
Nov 26, 2011·International Urology and Nephrology·Miklos Z MolnarLaszlo Rosivall
Apr 28, 2010·Journal of General Internal Medicine·Gaurav GuptaPeggy B Hasley
Oct 29, 2011·Irish Journal of Medical Science·C KennedyC Magee
May 23, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Gillian M Keating, Katherine A Lyseng-Williamson
Oct 28, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·James Neuberger
Nov 26, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Daniel BentenMartina Sterneck
Nov 25, 2006·Nature Clinical Practice. Nephrology·Millie SamaniegoArjang Djamali
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anton Y PelegDavid L Paterson
Sep 11, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Brenda C M de Winter, Teun van Gelder
Jan 19, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Manfred HeckingUNKNOWN European-New-Onset Diabetes After Transplantation Working Group
Aug 26, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuxia CuiRichard S Paules
Apr 25, 2007·Transplantation·Mario Abbud-FilhoFrancis L Delmonico
Jun 15, 2007·Transplantation·Julio PascualMilagros D Samaniego
Aug 19, 2007·Transplantation·Gabriel M DanovitchSuphamai Bunnapradist
Nov 7, 2007·Transplantation·Nyingi KemmerGuy W Neff
Jan 1, 2008·Transplantation·Timothy A Weaver, Allan D Kirk
Sep 25, 2008·Transplantation·Henrik Ekberg
Mar 20, 2009·Transplantation·Katherine A BarracloughUNKNOWN Genome Canada Biomarkers in Transplantation Group
Mar 21, 2009·Transplantation·Gerhard OpelzUNKNOWN Collaborative Transplant Study
May 20, 2011·Transplantation·Ben SprangersYves Vanrenterghem
Jul 27, 2011·Transplantation·Lisa M McDevitt-PotterSteven Gabardi

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