PMID: 18719314Aug 23, 2008Paper

Immunosuppression induced by a conditioned stimulus associated with cocaine self-administration

Journal of Pharmacological Sciences
Marta KuberaWładysław Lason

Abstract

Cocaine addiction is known to impair immune system function, but the effects of repeated treatment with cocaine in a self-administration model, its withdrawal as well as reinstatement of cocaine-seeking behavior on cell-mediated immunity are not well known. Cocaine self-administered for 18 days induced a significant increase in spleen weight, plasma corticosterone levels, interleukin (IL)-10, and tumor necrosis factor-alpha production, while concanavalin A-stimulated proliferation responses of peripheral blood T-lymphocytes and interferon-gamma production by splenic lymphocytes were not altered. After 10 days withdrawal from cocaine, reinstatement of cocaine seeking behavior induced either by a priming dose of the drug (unconditioned stimulus), by cue previously associated with cocaine self-administration (conditioned stimuli), or by both these stimuli evoked similar changes in several immunological parameters, for example, a decrease in relative spleen weight, proliferative activity of splenocytes, and their ability to produce IL-10. The results showed that the cue previously associated with cocaine suppressed some parameters of cell-mediated immunity to the same degree as re-exposure to cocaine. The present study provides the...Continue Reading

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Citations

Mar 1, 2014·TheScientificWorldJournal·John R RichardsChris S Clingan
Jul 31, 2013·Psychiatry Research·Mateus L LevandowskiRodrigo Grassi-Oliveira
Apr 20, 2013·Neuroscience Letters·Joana C M NarvaezFlávio Kapczinski
Jun 15, 2016·Neuroscience Letters·Mateus Luz LevandowskiRosa Maria Martins de Almeida
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Aug 20, 2011·Journal of the International Association of Providers of AIDS Care·Iliana Alexandra Angulo-ArreolaSteffanie A Strathdee
Dec 22, 2017·Trends in psychiatry and psychotherapy·Silvia Bassani Schuch-GoiLisia von Diemen

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