Immunosuppression Is Associated With Clinical Features and Relapse Risk of B Cell Posttransplant Lymphoproliferative Disorder: A Retrospective Analysis Based on the Prospective, International, Multicenter PTLD-1 Trials

Transplantation
H ZimmermannR U Trappe

Abstract

Current guideline recommendations for immunosuppression reduction after diagnosis of posttransplant lymphoproliferative disorder (PTLD) include stopping antimetabolites, reducing calcineurin inhibitors, and maintaining corticosteroids. However, the effect of immunosuppression on PTLD relapse risk after up-to-date therapy is unclear. This is a retrospective analysis of immunosuppression, patient baseline characteristics, and relapse risk measured as landmark time to progression (TTP) starting 1 year after start of therapy in 159 patients with B cell PTLD after solid organ transplantation treated in the prospective, international, multicenter PTLD-1 trials with either sequential treatment (rituximab followed by cyclophosphamide (CHOP-21 chemotherapy) 750 mg/m intravenously [IV] day (d) 1, doxorubicin 50 mg/m IV d1, vincristine 1.4 mg/m (maximum, 2 mg) IV d1, and prednisone 50 mg/m PO d1-5, every 21 days) or risk-stratified sequential treatment (rituximab followed by rituximab or rituximab (R-CHOP-21 immunochemotherapy) 375 mg/m IV day (d) 1, cyclophosphamide 750 mg/m IV d1, doxorubicin 50 mg/m IV d1, vincristine 1.4 mg/m (max. 2 mg) IV d1, and prednisone 50 mg/m PO d1-5, every 21 days). Patient baseline characteristics at diagnos...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gerhard Opelz, Bernd Döhler
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gerhard OpelzUNKNOWN Collaborative Transplant Study
Apr 23, 2010·British Journal of Haematology·Anne ParkerUNKNOWN Haemato-oncology Task Force of the British Committee for Standards in Haematology and British Transplantation Society
Jan 12, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R ReshefD E Tsai
Jun 26, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Nolwenn RabotJacques Dantal
Apr 11, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C Krisl, V P Doan

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Citations

Jul 25, 2019·Archives of Pathology & Laboratory Medicine·Alejandro A GruAndrea L Salavaggione
Nov 11, 2019·Abdominal Radiology·Abdelrahman K HanafyKhaled M Elsayes
May 13, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kira EndénTimo Jahnukainen

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