Abstract
Experimental allergic encephalomyelitis (EAE), induced by central nervous system (CNS) myelin basic protein (MBP) in adjuvant, is considered a thymus dependent autoimmune disease. Brain contains the thymic antigen, thy 1. The possibility that brain associated anti thy 1 immunoglobulin may be provoked in certain pathologic conditions of the CNS suggested a comparative evaluation of brain and thymocyte antisera on the development of EAE. Antisera produced in rabbits against brain from guinea pigs, rats and mice or fetal guinea pig thymus were highly reactive against thy 1 containing cells when assessed by indirect immunofluorescent staining or complement-mediated cell lysis. Treatment of guinea pigs with heteroantisera to guinea pig and mouse, but not to rat brain, for 3 days around the time of MBP sensitization markedly reduced physical signs of disease, particularly paralysis, but had little effect on the development of inflammatory lesions in the CNS. Anti-guinea pig thymocyte sera eliminated all physical signs of EAE with only residual pathology. These results establish the relative immunosuppressive effect of brain and thymocyte antisera in EAE and corroborate the thymus-dependent nature of EAE in guinea pigs.
References
May 1, 1976·European Journal of Immunology·R ArndtH G Thiele
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·A F WilliamsR J Morris
Jun 1, 1976·Cellular Immunology·V L SatoL A Herzenberg
Jan 1, 1977·Cellular Immunology·O W Press, C Rosse
Feb 1, 1975·European Journal of Immunology·G E RoelantsA Rydén
Nov 1, 1972·The Journal of Experimental Medicine·T C Douglas
Nov 29, 1974·Science·N K Gonatas, J C Howard
Mar 16, 1968·Lancet·S LeibowitzM H Lessof
Sep 27, 1969·British Medical Journal·E J Field
Aug 1, 1971·Cellular Immunology·E S Golub
Aug 1, 1972·The Journal of Experimental Medicine·E S Golub
Jan 1, 1969·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·W BrendelR Roscher
Jan 1, 1969·International Archives of Allergy and Applied Immunology·P C Dau, R D Peterson
Dec 1, 1965·The Journal of Experimental Medicine·J R David, P Y Paterson
Dec 1, 1967·Science·M E BlawR A Good
Sep 1, 1996·Immunity·J R GormanF W Alt
May 1, 1963·The Journal of Experimental Medicine·P Y PATERSON, S M HARWIN
Dec 1, 1961·The Journal of Experimental Medicine·B H WAKSMANB G ARNASON
Jan 1, 1960·The Journal of Experimental Medicine·P Y PATERSON
Sep 1, 1961·Science·S H Stone