Immunosuppression with mycophenolate mofetil attenuates the development of hypertension and albuminuria in deoxycorticosterone acetate-salt hypertensive rats.

Clinical and Experimental Pharmacology & Physiology
Erika I BoesenD M Pollock

Abstract

1. The interplay between the immune and renin-angiotensin systems is emerging as a crucial factor in the development and progression of hypertension. The aim of the present study was to determine the involvement of immune cells in the hypertension and renal injury produced by a non-angiotensin II-dependent form of hypertension, namely deoxycorticosterone acetate (DOCA)-salt-induced hypertension, in rats. 2. Male Sprague-Dawley rats underwent uninephrectomy and received either a sustained-release pellet of DOCA s.c. and 0.9% NaCl (saline) to drink for 21 days or a placebo pellet and water to drink for 21 days. Additional groups of DOCA-salt- and placebo-treated rats were treated concurrently with the immune suppressant mycophenolate mofetil (MMF; 30 mg/kg per day). Rats were placed in metabolic cages for 24 h urine collection prior to and at weekly intervals during the 21 day experimental period. 3. Mycophenolate mofetil significantly attenuated the development of hypertension in DOCA-salt rats compared with untreated DOCA-salt hypertensive rats (mean arterial pressure by telemetry on Day 18,146 ± 7 vs 180 ± 3 mmHg, respectively; P < 0.001), as well as proteinuria (87 ± 27 vs 305 ± 63 mg/day, respectively, on Day 21) and albumin...Continue Reading

References

Dec 1, 1995·Journal of Hypertension·A BataillardJ Sassard
Dec 1, 1995·Journal of Hypertension·C RenaudinJ Sassard
Jun 16, 2001·American Journal of Physiology. Renal Physiology·D M Pollock, J S Pollock
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Naohito IshiiPamela K Carmines
Jan 15, 2002·American Journal of Physiology. Renal Physiology·Bernardo Rodríguez-IturbeHéctor A Pons
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Violeta AlvarezBernardo Rodríguez-Iturbe
Apr 8, 2003·Journal of the American College of Cardiology·John M FlackElijah Saunders
Aug 18, 2005·Kidney International·Valentina VanegasBernardo Rodríguez-Iturbe
Nov 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dexter L LeeMichael W Brands
Oct 17, 2006·American Journal of Physiology. Heart and Circulatory Physiology·N TianR D Manning
Oct 31, 2006·Journal of Pharmacological Sciences·Ryuzea MiuraTohru Ohe
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Jose HerreraBernardo Rodriguez-Iturbe
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Eun A KoErnesto L Schiffrin
May 4, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Martha FrancoBernardo Rodríguez-Iturbe
Sep 19, 2007·The Journal of Experimental Medicine·Tomasz J GuzikDavid G Harrison
Feb 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kimberly R PechmanDavid L Mattson
May 23, 2008·American Journal of Physiology. Renal Physiology·Steven D CrowleyThomas M Coffman
Dec 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nyssa E HochDavid G Harrison
Jan 13, 2009·Current Problems in Cardiology·Krishna K GaddamDavid A Calhoun
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrés A HerradaAlexis M Kalergis
Feb 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carmen De MiguelDavid L Mattson

❮ Previous
Next ❯

Citations

May 30, 2013·Clinical and Experimental Pharmacology & Physiology·Wararat KittikulsuthDavid M Pollock
Jun 8, 2012·American Journal of Physiology. Renal Physiology·Wararat KittikulsuthDavid M Pollock
Feb 19, 2014·Current Hypertension Reports·Keisa W MathisMichael J Ryan
Apr 2, 2014·European Heart Journal·Noureddine Idris-KhodjaErnesto L Schiffrin
Aug 26, 2014·American Journal of Hypertension·Bernardo Rodríguez-IturbeRichard J Johnson
Jul 16, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kymberly D Watt
May 30, 2006·Journal of Neuroimmunology·Kai-Yun ZhuSara Fuchs
Jun 14, 2018·Physiology·Amrita V PaiKathryn Sandberg
Apr 11, 2018·American Journal of Physiology. Renal Physiology·Takahiro YamauchiTakao Masaki
May 4, 2011·Hypertension·Jasenka ZubcevicJulian F R Paton
Apr 20, 2016·F1000Research·Pauline M Smith, Alastair V Ferguson
Jul 4, 2018·British Journal of Pharmacology·Gisele Facholi BomfimFernando S Carneiro
Jul 19, 2014·Current Opinion in Nephrology and Hypertension·Jennifer L Gooch, Avadhesh C Sharma
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Jun 13, 2019·International Journal of Hypertension·Daniela Maria TanaseMariana Floria
Dec 25, 2015·American Journal of Physiology. Renal Physiology·Zhengrong GuanEdward W Inscho
Dec 28, 2012·American Journal of Physiology. Renal Physiology·Zhengrong GuanEdward W Inscho
Jun 6, 2018·Frontiers in Physiology·Arthur D MoesEwout J Hoorn
Aug 4, 2012·American Journal of Physiology. Renal Physiology·Xu JiNaoharu Iwai
Sep 18, 2021·Clinical Science·Erika I Boesen, Rahul M Kakalij

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Renal Physiology
D M PollockJennifer S Pollock
American Journal of Physiology. Heart and Circulatory Physiology
Sachin S Kandlikar, Gregory D Fink
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Ahmed A ElmarakbyD M Pollock
© 2021 Meta ULC. All rights reserved