PMID: 2114421May 1, 1990Paper

Immunosuppressive activity in human embryo growth media is associated with successful pregnancy: effect of gonadotropin releasing hormone agonist (GnRHa) treatment of patients undergoing in vitro fertilization and embryo transfer (IVF-ET)

Journal of Clinical Immunology
R Bose, M Mahadevan

Abstract

The aim of the present study was to determine whether the secretion of embryo-associated immunosuppressor factor (EASF) by preimplantation embryo correlates with pregnancy outcome and whether this relationship is influenced by pretreatment of gonadotropin releasing hormone agonist (GnRHa) in patients undergoing in vitro fertilization and embryo transfer (IVF-ET). EASF activity was measured using concanavalin A-induced human lymphocyte proliferation assay in 256 embryo growth media obtained from 61 patients undergoing IVF-ET. EASF activity was then correlated with GnRHa treatment and pregnancy outcome in these IVF patients. Results indicate that (i) the presence of immunosuppressive activity in human embryo growth media is associated with success of pregnancy in GnRHa nontreated patients and (ii) serum factors present in GnRHa-treated patients may affect the EASF secretion by preembryos in vitro.

References

Feb 1, 1989·Journal of in Vitro Fertilization and Embryo Transfer : IVF·D T ArmstrongL Denver
Apr 1, 1989·American Journal of Obstetrics and Gynecology·R BoseJ Fleetham
Jan 1, 1988·Annals of the New York Academy of Sciences·R FrydmanJ Testart
Aug 1, 1987·Journal of in Vitro Fertilization and Embryo Transfer : IVF·P ClamanM L Taymor
Jul 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·S Daya, D A Clark
Jan 1, 1985·Annals of the New York Academy of Sciences·J G Grudzinskas, A M Nysenbaum
May 1, 1982·Fertility and Sterility·B E Rolfe
Sep 1, 1983·Fertility and Sterility·A Lopata
Aug 1, 1982·Fertility and Sterility·J LeetonC Wood

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Citations

Jul 1, 1996·Journal of Assisted Reproduction and Genetics·D A ClarkI Craft
Dec 24, 1997·Journal of Assisted Reproduction and Genetics·A C Cavanagh
Aug 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M KamadaT Aono
Sep 1, 1993·American Journal of Reproductive Immunology : AJRI·R BoseJ A McCoshen
Sep 1, 1994·American Journal of Reproductive Immunology : AJRI·R Bose, A Berczi
May 1, 1995·American Journal of Reproductive Immunology : AJRI·R Bose, A G Lacson

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