Immunosuppressive effect of cyclosporin A on resistance to systemic infection with Candida albicans

Journal of Medical Microbiology
A VecchiarelliF Bistoni

Abstract

We studied the influence of cyclosporin-A (Cy-A) on resistance of mice to systemic infection with Candida albicans. Cy-A clearly inhibited resistance to C. albicans. The effect was dose-dependent and time and route of administration of the drug were important. This immunodepressive effect was due, at least in part, to an impairment of polymorphonuclear leucocyte (PMNL) candidacidal activity, as demonstrated in vitro by a reduction of phagocytic and cytotoxic activity and in vivo by protection when PMNL from untreated mice were transferred into cyclophosphamide-treated hosts challenged with C. albicans. The decreased activity of PMNL could be partly restored by adoptive transfer of normal T-lymphocytes into Cy-A-treated mice, as well as by exposure of PMNL to gamma-interferon (IFN-gamma) in vitro.

Citations

Mar 21, 1998·Bioorganic & Medicinal Chemistry·R FringuelliA Vecchiarelli
Apr 28, 2010·The Journal of Experimental Medicine·Matthew B GreenblattLaurie H Glimcher
Sep 3, 2004·Journal of Periodontology·Giuseppe Alexandre RomitoNoedir Antônio Groppo Stolf
Mar 31, 2010·Leukemia & Lymphoma·Charulata RamaprasadDavid L Pitrak
Jun 7, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K PursellD Pitrak
Apr 18, 2018·Immunological Reviews·Benjamin GourbalMihai G Netea
Aug 9, 2003·Pesquisa odontológica brasileira = Brazilian oral research·Giuseppe Alexandre RomitoNoedir Antônio Stolf
Dec 1, 1994·Antimicrobial Agents and Chemotherapy·E RoilidesT J Walsh

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