PMID: 29483409Feb 28, 2018Paper

Immunosuppressive Environment in Tumors

Gan to kagaku ryoho. Cancer & chemotherapy
Chika Sakai, Hiroyoshi Nishikawa

Abstract

Tumor cells establish a unique circumstance called tumor microenvironment(TME)suitable for tumor development and progression. One ofthe most important advantages ofTME for tumor cells is immunosuppressive environment such as higher presence ofregulatory T(Treg)cells, which play a central role for establishment and maintenance of immunological selftolerance and homeostasis. CTLA-4 expressed by Treg cells prevents the maturation ofAPCs resulting in suppression ofT -cell activation. Inhibitory cytokines and adenosine produced by Treg cells are also responsible for their suppressive functions. Indeed, high infiltration of Treg cells has been observed in many tumor tissues and is associated with poor clinical outcomes. Treg cells are recruited into tumors via chemokines secreted by tumor cells and immune cells, and further expand in TME. It has recently been shown that the metabolism oftumor cells and infiltrated immune cells in TME is also important component for tumor immunosuppressive environment. Effector T(Teff)cells rely on glycolysis for their proliferation and effector function, whereas Treg cells predominantly employ oxidative phosphorylation for suppressive function. In TME, tumor cells uptake and utilize large amounts ofg...Continue Reading

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