Immunosuppressive level and other risk factors for basal cell carcinoma and squamous cell carcinoma in heart transplant recipients

Archives of Dermatology
A B FortinaA Peserico

Abstract

To examine risk factors for the development of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in a cohort of heart transplant (HT) recipients and, in particular, to evaluate the role of the cumulative doses of different immunosuppressive drugs. Prospective nonconcurrent study. A dermatology clinic at a university hospital. A total of 230 HT recipients 18 years or older at the time of transplantation with at least 3 years of follow-up. The risk of SCC and BCC in HT recipients and the relationship between development of SCC and BCC and cumulative doses of different immunosuppressive agents, controlling for other potential risk factors (age, sex, sunlight exposure, skin type, and presence of warts). The cumulative immunosuppressive drug dose 3 years after transplantation (calculated by a weighted linear combination of azathioprine, cyclosporine, and corticosteroid cumulative doses [WLC]) was independently associated with an increased risk of developing SCC but not BCC. On multivariate analysis, patients receiving a WLC higher than the 75th percentile 3 years after HT had a 4 times higher risk of SCC than recipients of a WLC lower than the 50th percentile 3 years after HT (95% confidence interval, 1.4-11.4; P =.008). ...Continue Reading

Citations

Feb 19, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·D Krüger-CorcoranC Ulrich
Oct 27, 2007·Actas dermo-sifiliográficas·R Corbalán-VélezF J Carapeto
Jul 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Virve KoljonenHeikki Mäkisalo
Sep 5, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Asa IngvarJohanna Adami
Feb 6, 2009·Melanoma Research·Edoardo ZattraMauro Alaibac
Nov 30, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Tejaswi MudigondaSteven R Feldman
Nov 28, 2012·Journal of Inflammation·Thais Helena GasparotoAna Paula Campanelli
Oct 8, 2011·PloS One·Ronald GlaserJanice K Kiecolt-Glaser
Oct 5, 2007·Current Rheumatology Reports·Johan Askling
Feb 3, 2016·Journal of the American Academy of Dermatology·Renhua NaClaire M Vajdic
Sep 4, 2015·The British Journal of Dermatology·B KrynitzK E Smedby
Dec 19, 2012·Journal of the American Academy of Dermatology·Darrell S Rigel, Linda F Stein Gold
Jun 20, 2012·Transplant Immunology·Hermina C WisgerhofJan N Bouwes Bavinck
Feb 22, 2012·Journal of the American Academy of Dermatology·Joshua P SpanogleClark C Otley
Apr 7, 2009·Transplantation Reviews·Bradley T Kovach, Thomas Stasko
Jan 6, 2009·The Journal of Investigative Dermatology·Hermina C WisgerhofFrank R de Gruijl
Aug 19, 2007·Transplantation Proceedings·S PiasericoF Marchini
Aug 22, 2015·Transplantation Proceedings·B Imko-WalczukB Rutkowski
Feb 2, 2008·International Journal of Cancer. Journal International Du Cancer·Marian Simka
May 10, 2006·Clinical and Experimental Dermatology·S TavadiaS Holmes
Mar 21, 2012·Clinical Transplantation·Eric DybbroSarah T Arron
Oct 15, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·J ValeroM Lahoz
Jun 29, 2011·Gastroenterology·Laurent Peyrin-BirouletUNKNOWN Cesame Study Group
Jul 4, 2016·Medical Hypotheses·David M ConradChristopher Naugler
May 11, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Z JiyadA C Green
Oct 2, 2012·Dermatologic Clinics·Joshua W HagenA Neil Crowson
Aug 9, 2016·Transplantation Proceedings·A CegielskaB Rutkowski
Feb 15, 2011·Journal of the American Academy of Dermatology·Ryan B TurnerEllen S Marmur
Jul 24, 2012·Biochemical and Biophysical Research Communications·Aadithya ArumugamMohammad Athar
Jan 11, 2017·The American Journal of Gastroenterology·Francis A FarrayeSunanda V Kane
Jul 5, 2012·Circulation·Georg Marcus FröhlichFrank Ruschitzka
Sep 28, 2006·The Journal of Craniofacial Surgery·Othon PapadopoulosGeorge Barlas
Nov 24, 2007·Virchows Archiv : an International Journal of Pathology·Sonja BoydUlpu Saarialho-Kere
Aug 26, 2010·Nature Reviews. Nephrology·Inés Rama, Josep M Grinyó
Oct 28, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Joyce H Y MaShyamala C Huilgol
Jan 30, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A E CoghillM M Madeleine

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