PMID: 6171029Jan 1, 1981Paper

Immunosuppressive properties of alpha 1-microglobulin

Scandinavian Journal of Immunology
L E Lögdberg, B Akerström

Abstract

alpha 1-Microglobulin (alpha 1m), a serum glycoprotein (26,000 d), was found to impede the proliferative response of human lymphocytes to purified protein derivative (PPD) and tetanus toxoid. The data suggest that alpha 1m operates through an unstable suppressor mechanism, which no longer can function after 24 h of preculturing. This effect of alpha 1m on antigen stimulation did not seem to be due to binding of alpha 1m to PPD or cells, to altered kinetics of the PPD response, or to non-specific cytotoxicity. In contrast, PPD-induced leucocyte migration was not reversed by alpha 1m. alpha 1m did not cause significant inhibition in experiments in which lymphocytes were stimulated by the mitogens phytohaemagglutinin or concanavalin A. Finally, alpha 1m had its own leucocyte migration inhibitory effect.

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Citations

Jul 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·B Kshirsagar, R C Wiggins
Nov 4, 2000·Biochimica Et Biophysica Acta·L Lögdberg, L Wester
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E MéndezF Leyva-Cobián
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Jul 17, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joris Penders, Joris R Delanghe
Jun 1, 1983·European Journal of Biochemistry·B Akerström
Nov 1, 1986·Scandinavian Journal of Immunology·L LögdbergE M Shevach
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Dec 1, 1984·Scandinavian Journal of Immunology·B Akerström, L Lögdberg
Sep 30, 1988·Biochemical and Biophysical Research Communications·J EscribanoE Méndez
May 7, 1998·Journal of Biomedical Materials Research·M A WassallS P Denyer
Oct 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L E LögdbergS Badve
Jan 15, 1985·European Journal of Biochemistry·B Akerström, B Landin
Apr 20, 2012·The Biochemical Journal·Winfried Meining, Arne Skerra
Oct 1, 1990·European Journal of Immunology·G LindahlL Stenberg
Sep 4, 2007·The Journal of Biological Chemistry·Bo AkerströmAnthony J Kettle
Nov 10, 2004·The Biochemical Journal·Jasjit S GrewalSaeed R Khan
Feb 3, 2005·Free Radical Biology & Medicine·Maria AllhornBo Akerström
Sep 11, 2010·Veterinary Immunology and Immunopathology·Junya NakataFumio Hoshi

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