PMID: 5814Dec 26, 1975

Immunosuppressive therapy in renal disease (author's transl)

Wiener klinische Wochenschrift
P Schmidt

Abstract

Since immunological events were found to be pathogenetically involved in various forms of glomerulonephritis, corticosteroids and immunosuppressive drugs were introduced in the treatment of nephritis. However, as opposed to the findings in the paediatric nephrotic syndrome, controlled and multicentric trials with immunosuppressive therapy revealed disappointing results in the management of renal disease in adults. Significantly better results under immunosuppressive therapy, were seen only in the nephrotic syndrome based on the so-called "no changes" or "minimal changes" nephritis. In chronic membranous and proliferative glomerulonephritis the clinical course in the treated group was not statistically different from that of the untreated group. In some disorders of connective tissues, such as systemic lupus erythematosus, polyarteritis nodosa and Wegener's granulomatosis, corticosteroids and immunosuppressive agents seem to exert a favourable effect on the course of renal disease. Encouraging results concerning the combined use of immunosuppressive drugs, anticoagulants and platelet aggregation inhibitors in mesangiocapillary (membrano-proliferative) glomerulonephritis and rapidly progressive nephritis have also been presented....Continue Reading

Related Concepts

Anti-Inflammatory Agents
Indirect Thrombin Inhibitors
Hemolytic Complement
Bacterial Endocarditis
Bright Disease
Therapeutic Immunosuppression
Kidney Diseases
Lupus Erythematosus, Systemic
Malaria
Nephritis

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