Immunosuppressive treatments for myelodysplastic syndromes

Leukemia & Lymphoma
T Shimamoto, K Ohyashiki

Abstract

The myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal hematopoietic stem cell disorders, while, immunological abnormalities are frequently observed in patients with MDS. Several reports revealed that about 10% of MDS patients have clinical autoimmune disorders like skin vasculitis, rheumatic disease, or autoimmune hemolytic anemia. Furthermore, serological immunological abnormalities like hyper- or hypogammaglobulinemia, positivities of antinuclear antibody, positivities of direct Coombs test, or inverted CD4/8 ratios were found in 18-65% of patients with MDS. Recently immunosuppressive therapies including prednisolone, antithymocyte globulin, and cyclosporin A (CsA) are used to treat cytopenia in some patients with MDS. We examined the efficacy of CsA in 50 patients with MDS. Hematologic improvement was observed in 30 (60%) patients especially for erythroid lineage. There were significantly more responders with good karyotype or DRB1*1501 than with intermediate/poor karyotypes or with other HLA types. MDS with erythroid hypoplasia is a rare form of MDS, and has not yet been clearly defined. We reported four patients with MDS with erythroid hypoplasia who had morphological evidence of myelodysplasia and l...Continue Reading

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Citations

Sep 9, 2008·Journal of Pediatric Hematology/oncology·Tadashi MatsubayashiJun Miyahara
Nov 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elaine M SloandNeal S Young
Jan 31, 2007·International Journal of Hematology·Shuchang ChenMei Guan
Feb 11, 2014·Best Practice & Research. Clinical Haematology·Thorsten Braun, Pierre Fenaux
Nov 21, 2012·Expert Opinion on Emerging Drugs·Pearlie K Epling-BurnetteAlan F List
Jan 9, 2008·Seminars in Hematology·Elaine M Sloand, Katayoun Rezvani
Apr 18, 2007·Experimental Dermatology·Maren WeischerMark Berneburg
Nov 5, 2003·Hematological Oncology

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