PMID: 6106528Nov 17, 1980Paper

Immunosympathectomy: lack of evidence for a complement-mediated cytotoxic mechanism

Brain Research
M GoedertH Thoenen

Abstract

To determine whether the destruction of peripheral sympathetic neurons by anti-NGF-antibodies results from a complement-mediated cytotoxic action or from the deprivation of endogenous NGF or immunologically NGF-like cross-reacting molecules we investigated the time-course of the reversibility of the effect of NGF-antibodies by neutralizing doses of NGF, together with the effect of NGF-antibodies in complement-deficient mice. After administration of a single dose of 50 mg/kg of purified antibodies to newborn rats the TH level was reduced to 75% of controls after 12 h, to 48% after 24 h, 39% after 36, and 28% after 48 h. After this time no further reduction occurred and levels remained constant up to 14 days. The effect of the NGF-antibodies was reversible on addition of NGF up to 48 h after antibody administration. Although the reversibility was not complete (85% of controls) the extent of the reversibility was the same whether NGF was given 12 or 48 h after the antibodies. The incompleteness of the reversibility is reflected by the small number of degenerating neurons apparent as early as 12 h after antibody administration. Since these early degenerative effects were also seen in complement-deficient mice it is concluded that t...Continue Reading

References

Nov 24, 1977·The New England Journal of Medicine·W C MobleyE M Shooter
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K SudaH Thoenen
Nov 17, 1977·The New England Journal of Medicine·W C MobleyE M Shooter
Jan 1, 1977·Advances in Protein Chemistry·A C Server, E M Shooter
Dec 1, 1977·The New England Journal of Medicine·W C MobleyE M Shooter
Jun 1, 1976·Journal of Neurochemistry·K StoeckelH Thoenen
Jan 1, 1975·Annual Review of Biochemistry·H J Müller-Eberhard
Jan 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·H ThoenenJ Axelrod
Jul 1, 1968·Physiological Reviews·R Levi-Montalcini, P U Angeletti
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·V Bocchini, P U Angeletti
Mar 1, 1970·Experimental Cell Research·E L Fenton
Jul 7, 1967·Biochemical Pharmacology·M LevittS Udenfriend

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Citations

Apr 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R Levi-Montalcini
May 20, 1982·Brain Research·E M JohnsonJ Pearson
Jun 1, 1995·Journal of the Neurological Sciences·R Levi-MontalciniA Leon
Jun 1, 1985·Journal of the Autonomic Nervous System·R GrzannaU Otten
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Y Dimberg, T Ebendal
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M GoedertU Otten
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M GoedertW Lichtensteiger
Dec 31, 1997·Journal of Neuroimmunology·J R Tonra, L M Mendell
Sep 1, 1987·Bioscience Reports·R Levi-Montalcini
Oct 1, 1989·Annals of Neurology·W D Snider, E M Johnson
Jun 1, 1990·The Journal of Comparative Neurology·B A Urschel, C E Hulsebosch
Sep 4, 1987·Science·R Levi-Montalcini

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