PMID: 8595128Nov 1, 1995Paper

Immunoteratology: I. MHC involvement in the embryo response to teratogens in mice

American Journal of Reproductive Immunology : AJRI
Arkady TorchinskyVladimir Toder

Abstract

The present study was carried out to evaluate an involvement of MHC-associated maternal immunoreactivity in response to environmental teratogens. Two chemicals, cyclophosphamide (CP) and 2,3-quinoxalinedimetanol, 1,4-dioxide (QD) were used as the reference teratogens (RT). The response to these RT was investigated in syngeneically and allogeneically mated CBA/J and C57B1/6 mice. In part of C57B1/6 female mice, paraaortic lymph nodes were extirpated 14 days before mating to allogeneic or syngeneic males. Twenty or 40 mg/kg of CP or 300 or 600 mg/kg of QD were injected on day 12 and 9 of pregnancy, accordingly (vaginal plug indicates day 1 of pregnancy). On day 19 of pregnancy implantation sites, resorption, live and dead fetuses were recorded and live fetuses were examined with methods routinely used in applied teratology. Both mice strains showed equal response to teratogens but the RT-induced effect was significantly weaker in allogeneic than syngeneic mouse combinations. Extirpation of draining lymph nodes dramatically increased the sensitivity to RT in allogeneically mated females but failed to alter that of syngeneically mated ones. The results of this study suggest that fetomaternal MHC incompatibility exerts the favourabl...Continue Reading

References

Jan 1, 1992·Immunogenetics·D VardimonT J Gill
Jan 1, 1991·Annals of the New York Academy of Sciences·D A ClarkC Harley
May 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·G Chaouat
Nov 1, 1983·The Journal of Experimental Zoology·T J GillH W Kunz
Dec 1, 1994·Clinical and Experimental Immunology·A TorchinskyV Toder
Apr 1, 1984·Immunology Today·D A ClarkJ Rossant

❮ Previous
Next ❯

Citations

Oct 1, 2011·Journal of Bone and Mineral Metabolism·Arkady TorchinskyEugene Kobyliansky
May 1, 1996·Journal of Reproductive Immunology·V ToderA Torchinsky
Feb 5, 2000·Journal of Reproductive Immunology·D YitzhakieV Toder
Oct 10, 1998·Cancer Practice·M Frank-Stromborg, L J Bailey
Feb 1, 1996·American Journal of Reproductive Immunology : AJRI·V Toder, A Torchinsky
May 12, 2007·The Review of Diabetic Studies : RDS·Keren MammonArkady Torchinsky
Mar 14, 2014·Archives of Toxicology·Eyal MorNoam Shomron
Aug 26, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Arkady TorchinskyVladimir Toder
Jun 24, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·S SavionV Toder
Jan 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·A FeinV Toder
Jul 31, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Olga PekarArkady Torchinsky
Mar 20, 2002·American Journal of Reproductive Immunology : AJRI·S SavionV Toder
Jun 12, 2003·American Journal of Reproductive Immunology : AJRI·Arkady TorchinskyVladimir Toder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved