Immunotherapeutic polyoma and human papilloma virus-like particles

Immunotherapy
Torbjörn Ramqvist, Tina Dalianis

Abstract

Polyomavirus and human papillomavirus (HPV) virus-like particles (VLPs) can be obtained by producing their major capsid protein VP1 (for polyomavirus) or L1 (for HPV) free from other viral genes in, for example, a baculovirus insect system, yeast, Escherichia coli or similar systems. Polyomavirus and HPV VLPs can immunize healthy individuals, and in some cases T-cell-deficient hosts, against primary infection with the corresponding virus. Chimeric VLPs from polyomaviruses or HPVs containing fusion proteins between the VP1/L1 or VP2/VP3/L2 minor capsid proteins and selected antigens can also be produced. These VLPs can then induce B- or T-cell immune responses and be used as preventive or therapeutic vaccines against cancers induced by the corresponding virus, or a cancer bearing the selected tumor antigen.

References

Sep 12, 1986·Cell·D M SalunkeR L Garcea
Oct 1, 1994·Journal of Comparative Pathology·J E GreenleeW G Stroop
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·H L GreenstoneJ T Schiller
Sep 17, 1998·The Journal of Biological Chemistry·U LindahlL Kjellén
Aug 12, 1999·Annals of Medicine·S M Syrjänen, K J Syrjänen
Feb 17, 2000·Trends in Biotechnology·A Mountain
Jan 11, 2001·Journal of Virology·T GiroglouM Sapp
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·A M KaufmannM Dürst
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P LenzJ T Schiller
Aug 17, 2001·Journal of Virology·L Chen, M Fluck
Jun 5, 2002·Nature Reviews. Cancer·Harald zur Hausen
Aug 20, 2002·The Journal of General Virology·Petra MannováJitka Forstová
Oct 11, 2002·Advances in Cancer Research·Rolf KiesslingB Seliger
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bryce ChackerianJohn T Schiller
Nov 22, 2002·The New England Journal of Medicine·Laura A KoutskyUNKNOWN Proof of Principle Study Investigators
Nov 26, 2002·Virus Research·Karl Münger, Peter M Howley
Apr 23, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Petra LenzJohn T Schiller
Aug 28, 2003·The EMBO Journal·Billy TsaiTom A Rapoport
Jan 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·L KILHAM, H W MURPHY
Nov 17, 2004·Current Pharmaceutical Biotechnology·Chava Kimchi-Sarfaty, Michael M Gottesman

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Citations

Jul 14, 2012·Immunotherapy·Tina Dalianis
Oct 23, 2014·Journal of the American Medical Informatics Association : JAMIA·Hanna SuominenBarbara Kelly

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Methods Mentioned

BETA
ELISA
transgenic

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