Immunotherapeutics to Treat HIV in the Central Nervous System.

Current HIV/AIDS Reports
Andrew Kapoor, C Sabrina Tan

Abstract

The application of immunotherapies to HIV presents a new horizon of treatment options, but little is known about what impact they may have on the central nervous system (CNS). Here we review the most promising immunotherapeutic strategies that can be used to target HIV in the CNS and focus on identifying their potential benefits while exploring the challenges that remain in their application. We have identified five immunotherapeutic strategies that hold potential in managing CNS disease among HIV-infected patients. These include broadly neutralizing antibodies, multi-affinity antibodies, CAR-T cell therapy, checkpoint inhibitors, and therapeutic vaccines. Each class of immunotherapy presents unique mechanisms by which CNS viremia and latency may be addressed but are faced with several challenges. CAR-T cell therapy and multi-affinity antibodies seem to hold promise, but combination therapy is likely to be most effective. However, more human trials are needed before the clinical benefits of these therapies are realized.

References

Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·O O YangB D Walker
Oct 24, 2002·Blood·James L RubensteinMarc A Shuman
Jul 14, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ann DuerrLawrence Corey
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth ConnickPamela J Skinner
May 10, 2008·Science·Bruce D Walker, Dennis R Burton
Dec 17, 2008·Nature·Vijayakumar VeluRama Rao Amara
Oct 22, 2009·The New England Journal of Medicine·Supachai Rerks-NgarmUNKNOWN MOPH-TAVEG Investigators
Jan 27, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ana CanestriChristine Katlama
Dec 31, 2010·Current HIV/AIDS Reports·Victor ValcourBeau Ances
Mar 17, 2011·Infectious Disorders Drug Targets·Jean B NachegaRobert Gross
Dec 14, 2011·The Journal of Antimicrobial Chemotherapy·Aylin YilmazMagnus Gisslén
Dec 27, 2011·Current HIV/AIDS Reports·Filippos Porichis, Daniel E Kaufmann
May 4, 2012·Science Translational Medicine·John SchollerCarl H June
Oct 18, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leslie L MuldoonEdward A Neuwelt
Feb 23, 2013·Current Opinion in HIV and AIDS·Melissa Churchill, Avindra Nath
Sep 10, 2014·Current Opinion in HIV and AIDS·Lachlan R GrayMelissa J Churchill
Nov 8, 2014·Science Translational Medicine·Y Joy YuRyan J Watts
May 21, 2015·Nature Immunology·Tae-Wook ChunAnthony S Fauci
Oct 27, 2015·Pharmacotherapy·Ninh M La-BeckDevin B Lowe
Dec 3, 2015·Expert Review of Clinical Immunology·Jean-Pierre RoutyWei Cao
Jan 6, 2016·The Journal of Clinical Investigation·R Brad Jones, Bruce D Walker
Jan 12, 2016·The Journal of Clinical Investigation·Ariel Halper-Stromberg, Michel C Nussenzweig
Aug 19, 2016·Current Opinion in HIV and AIDS·Jean-Louis Excler, Nelson L Michael
Sep 15, 2016·Molecular Therapy Oncolytics·Challice L BonifantKevin J Curran
Oct 18, 2016·Frontiers in Immunology·Céline MarbanChristian Schwartz
Jan 9, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S CuzzubboA F Carpentier
Jan 31, 2017·Immunological Reviews·Stylianos Bournazos, Jeffrey V Ravetch
Mar 31, 2017·Immunotherapy·Anjie ZhenScott G Kitchen
Jul 12, 2017·Expert Review of Anti-infective Therapy·Jon HuygheLinos Vandekerckhove
Sep 20, 2017·Nature Reviews. Clinical Oncology·Sattva S NeelapuElizabeth J Shpall
Oct 17, 2017·Annual Review of Medicine·Lucio Gama, Richard A Koup
Nov 4, 2017·Annual Review of Medicine·Adam M Spivak, Vicente Planelles
Dec 6, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GuihotJ-P Spano
Jan 18, 2018·The New England Journal of Medicine·David M Margolis, J Victor Garcia
Mar 4, 2018·Current HIV/AIDS Reports·Thor A Wagner
Apr 5, 2018·Viruses·Yong GaoJamie F S Mann
Apr 27, 2018·Current Opinion in HIV and AIDS·Yehuda Z Cohen, Marina Caskey
Jun 8, 2018·Current Opinion in HIV and AIDS·Anne-Sophie KuhlmannHans-Peter Kiem
Jun 30, 2018·Current Opinion in HIV and AIDS·Kathryn E Stephenson

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