PMID: 18406756Sep 1, 1996Paper

Immunotherapies in diabetes

Trends in Endocrinology and Metabolism : TEM
V K Ramiya, N K Maclaren

Abstract

Insulin-dependent diabetes (IDD) is a serious, life-long disease replete with life-threatening complications that are not preventable through conventional insulin replacement therapies. The prolonged prodromal period of autoimmunity to beta cell antigens offers multiple intervention opportunities. These can target different steps that precede final destruction of insulin-secreting beta cells and clinical onset of the disease. All current and proposed immunotherapies are experimental procedures that have proven to be protective in animal models, especially the nonobese diabetic (NOD) mouse. This brief review deals with a selected list of nonspecific and autoantigen-specific immunotherapies that may bring hope in the near future to individuals at risk of developing the disease. None are yet proven to be effective in humans.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S D SharmaS Sriram
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Z J ZhangH L Weiner
Mar 2, 1989·The New England Journal of Medicine·S C ShahN E Simpson
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·X D YangH O McDevitt
Dec 1, 1993·Diabetes/metabolism Reviews·H J HahnF Emmrich
Jun 1, 1994·Scandinavian Journal of Immunology·A G BaxterA Cooke
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·L ChatenoudJ F Bach

❮ Previous
Next ❯

Citations

Sep 14, 2001·Best Practice & Research. Clinical Endocrinology & Metabolism·F K GorusUNKNOWN Belgian Diabetes Registry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.