Immunotherapy as a strategy for treatment of leishmaniasis: a review of the literature

Immunotherapy
Ifeoma Okwor, Jude E Uzonna

Abstract

Leishmaniasis occurs as a spectrum of clinical syndromes divided into cutaneous, mucocutaneous and visceral forms. The epidemiology and clinical features are highly variable owing to the interplay of many factors ranging from parasite species and strains, vectors, host genetics and environment. Currently, there is no effective licensed vaccine for use in humans against leishmaniasis. Most traditional and low-cost treatment options, particularly in poor and endemic areas, are toxic with many adverse reactions and they require a long course of administration. The use of more effective, less toxic drugs is limited because total treatment cost is very high (expensive) and there are fears of development of drug resistance. Recent studies indicate that certain strategies aimed at modulating the host immune response (collectively called immunotherapy) could result in prophylactic and/or therapeutic cure of leishmaniasis under both laboratory and field conditions. In this review, we focus on treatment of leishmaniasis with a particular emphasis on immunotherapy/immunochemotherapy as an alternative to conventional drug treatment.

References

Mar 1, 1992·The American Journal of Tropical Medicine and Hygiene·B L Herwaldt, J D Berman
Jan 1, 1992·Advances in Parasitology·J Alexander, D G Russell
Mar 1, 1991·Immunology Today·T R Mosmann, K W Moore
Mar 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·G HarmsU Bienzle
Apr 1, 1989·Experimental Parasitology·P Scott
Jul 1, 1989·The Journal of Infectious Diseases·J ConvitL Valecillos
Nov 1, 1988·Oncology Nursing Forum
Jun 1, 1988·The Journal of Experimental Medicine·M J McElrathZ A Cohn
Jan 1, 1995·Annual Review of Immunology·S L Reiner, R M Locksley
May 1, 1993·The Journal of Experimental Medicine·F P HeinzelM K Gately
Jan 1, 1993·Advances in Parasitology·F Y Liew, C A O'Donnell
May 1, 1993·Infection·Y LermanY L Danon
Sep 1, 1996·Clinics in Dermatology·O GenaroW Mayrink
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A Ribeiro-de-JesusE M Carvalho
Sep 2, 1998·Current Opinion in Immunology·J LouisP Launois
May 13, 1999·Parasite Immunology·R ChatelainR L Coffman
Feb 1, 2000·Immunology Today·C R Engwerda, P M Kaye
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H HimmelrichJ A Louis
May 16, 2000·Immunology·M CumberbatchI Kimber
May 29, 2000·Vaccine·E HandmanA Sjölander
Jun 3, 2000·Annual Review of Immunology·S GurunathanR A Seder
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A Y ParkP Scott
Mar 23, 2001·Nature Immunology·M Moser, K M Murphy
Oct 29, 2000·Advances in Virus Research·H L Robinson, T M Pertmer
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M M Kane, D M Mosser
Mar 17, 2001·The Journal of Antimicrobial Chemotherapy·F BarchiesiM A Viviani
Jul 14, 2001·Antimicrobial Agents and Chemotherapy·H W Murray

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Citations

Nov 16, 2013·Nature Chemical Biology·Jacques Neefjes, Huib Ovaa
Apr 19, 2012·PLoS Pathogens·Subir KarmakarTripti De
Aug 5, 2014·Journal of Colloid and Interface Science·Muzamil Yaqub WantFarhat Afrin
Jul 15, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Hossein Yousofi DaraniRasool Jafari
Aug 27, 2014·Future Microbiology·Forough Khadem, Jude E Uzonna
Mar 9, 2012·Expert Review of Anti-infective Therapy·Marie-Thérèse Labro
Dec 14, 2011·Expert Review of Vaccines·Delaram Doroud, Sima Rafati
Aug 1, 2014·Expert Opinion on Biological Therapy·Ali Khamesipour
Dec 15, 2015·EURASIP Journal on Bioinformatics & Systems Biology·Piyali GanguliRam Rup Sarkar
Aug 20, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P M Kaye, T Aebischer
Dec 19, 2017·PLoS Neglected Tropical Diseases·Zahra AbdossamadiSima Rafati
May 8, 2018·BMJ Global Health·Lisa-Marie ThomasDina Balabanova
Aug 24, 2019·Frontiers in Cellular and Infection Microbiology·Alejandro L AntoniaDennis C Ko
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Ana Alice Maia GonçalvesRodolfo Cordeiro Giunchetti
Mar 28, 2021·Immunology Letters·Maryam AkbariGholamreza Hatam
Sep 5, 2021·Clinical and Experimental Dermatology·S PradhanM Goldust

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