Immunotherapy for Gastric Cancer: Time for a Personalized Approach?

International Journal of Molecular Sciences
Riccardo DolcettiVincenzo Canzonieri

Abstract

Over the last decade, our understanding of the mechanisms underlying immune modulation has greatly improved, allowing for the development of multiple therapeutic approaches that are revolutionizing the treatment of cancer. Immunotherapy for gastric cancer (GC) is still in the early phases but is rapidly evolving. Recently, multi-platform molecular analyses of GC have proposed a new classification of this heterogeneous group of tumors, highlighting subset-specific features that may more reliably inform therapeutic choices, including the use of new immunotherapeutic drugs. The clinical benefit and improved survival observed in GC patients treated with immunotherapeutic strategies and their combination with conventional therapies highlighted the importance of the immune environment surrounding the tumor. A thorough investigation of the tumor microenvironment and the complex and dynamic interaction between immune cells and tumor cells is a fundamental requirement for the rational design of novel and more effective immunotherapeutic approaches. This review summarizes the pre-clinical and clinical results obtained so far with immunomodulatory and immunotherapeutic treatments for GC and discusses the novel combination strategies that ...Continue Reading

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Citations

Sep 6, 2019·Cancer Metastasis Reviews·Alessio BiagioniLaura Papucci
Jul 4, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Simon PernotJulien Taieb
Mar 15, 2020·Journal of Leukocyte Biology·Maria Grazia RefoloRosalba D'Alessandro
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Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger
Dec 10, 2021·Personalized Medicine·Khalil El GharibHampig Raphael Kourie

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Methods Mentioned

BETA
genetic modification
biopsies
xenografts

Clinical Trials Mentioned

NCT02713984
NCT02689284
NCT02864381
NCT02730546

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