Immunotherapy for Non-small Cell Lung Cancer: Current Landscape and Future Perspectives

Immune Network
Sun Min LimHye Ryun Kim

Abstract

Immune checkpoint inhibitors (ICIs) have shown remarkable benefit in the treatment of patients with non-small-cell lung cancer (NSCLC) and have emerged as an effective treatment option even in the first-line setting. ICIs can block inhibitory pathways that restrain the immune response against cancer, restoring and sustaining antitumor immunity. Currently, there are 4 PD-1/PD-L1 blocking agents available in clinics, and immunotherapy-based regimen alone or in combination with chemotherapy is now preferred option. Combination trials assessing combination of ICIs with chemotherapy, targeted therapy and other immunotherapy are ongoing. Controversies remain regarding the use of ICIs in targetable oncogene-addicted subpopulations, but their initial treatment recommendations remained unchanged, with specific tyrosine kinase inhibitors as the choice. For the majority of patients without targetable driver oncogenes, deciding between therapeutic options can be difficult due to lack of direct cross-comparison studies. There are continuous efforts to find predictive biomarkers to find those who respond better to ICIs. PD-L1 protein expressions by immunohistochemistry and tumor mutational burden have emerged as most well-validated biomarker...Continue Reading

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Citations

Apr 9, 2020·International Journal of Molecular Sciences·Min Hwa ShinKyung-Mi Lee
Jan 14, 2021·Survey of Ophthalmology·Carmen Alba-Linero, Emilio Alba
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Clinical Trials Mentioned

NCT02671955
NCT01391143
NCT02475213
NCT00844064
NCT01968109
NCT02460224
NCT00732082
NCT00349934
NCT02864251
NCT03256136

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